ACEIs and ARBs Exam Practice Questions and Answers

ACEIs and ARBs Exam Practice Questions and Answers What are the Angiotensin Converting Enzyme Inhibitors (ACEIs)? - Correct Answer ️️ - "-pril" Benazepril Captopril Enalapril Enalaprilat Fosinopril Lisinopril Moexipril Perindopril Quinapril Ramipril Trandolapril What are the Angiotensin Receptor Blockers (ARBs)? - Correct Answer ️️ -"-sartan" Azilsartan Candesartan Eprosartan Irbesartan Losartan Olmesartan Telmisartan Valsartan What is the alpha-2 agonist that blocks renin secretion? - Correct Answer ️️ -Clonidine What is the nonspecific beta antagonist that blocks renin secretion? - Correct Answer ️️ -Propranolol What is the renin inhibitor drug? - Correct Answer ️️ -Aliskiren What factors stimulate renin release? - Correct Answer ️️ -Decrease in blood pressure Decrease in fluid volume Increase in beta-1 sympathetics What factors inhibit renin release? - Correct Answer ️️ -Increase in blood pressure Increase in fluid volume Decrease in beta-1 sympathetics ANP What is Renin's role in RAAS? - Correct Answer ️️ -Catalyzes the hydrolytic release of the decapeptide angiotensin I from angiotensinogen. It enters circulation from the kidneys, where it is synthesized and stored in the juxtaglomerular apparatus of the nephron. Sympathetic nervous system stimulation causes activation of beta-1 adrenergic receptors on juxtaglomerular cells, which stimulates the release of renin from these cells. What is Angiotensinogen's role in RAAS? - Correct Answer ️️ -Synthesized in the liver from which renin cleaves angiotensin I. Angiotensinogen production is increased by corticosteroids, estrogens, thyroid hormones, and angiotensin II. What is Angiotensin I's role in RAAS? - Correct Answer ️️ -Has little to no biologic activity. Cleaved to angiotensin II by angiotensin converting enzyme (ACE