Chagas Disease
Caused by Trypanosoma cruzi parasite
passed in the feces of Reduviidae/kissing
bug Penetrates broken skin or intact
mucous membranes forming a
pseudocyst releasing inflammatory
infiltrates into myocytes; stains with
Giemsa & W right Romana sign occurs
when portal of entry is the conjunctiva or
eyelid May resulting in: Enlarged heart-
CHF, sudden cardiac arrest Enlarged
esophagus- dif ficulty swallowing Enlarged
colon- abdominal pain or constipation
Treat with benznidazole or nifurtimox
Monocytes
cell with half-moon shaped nucleus that
participates in phagocytosis
Chronic graft rejection
multifactorial but typically involves
arteriosclerosis HLA-B27
PAIR: Psoriasis Ankylosing spondylitis-
chronic synovitis destroying cartilage
typically in young men Inflammatory
bowel dz- Crohn's & UC Reactive
Arthritis-
Reactive Arthritis
Arthritis as a reaction to a bacterial
infection such as Campylobacter ,
Chlamydia, Salmonella, Shigella, or
Ureaplasma. Associated with
conjunctivitis & uveitis
Gaucher (T ype 1)
AR L ysosomal storage disease
Accumulation of sphingolipid
glucocerebroside Most common W rinkled
tissue paper I Cell disease
Failure of Golgi apparatus to
phosphorylate mannose 6-phosphate the
marker to export enzymes to lysosomes
resulting in accumulation of lysosomal
enzymes in serum
Nitroblue tetrazolium test
Aqualitative test to determine defects in
NADPH oxidase Negative: CGD Positive:
Acute Hepatitis, Mono
CGD (chronic granulomatous disease)
inability to produce NADPH oxidase;
susceptible to Cat + organisms; elevated
neutrophils w/ normal T cell Gp91 phox
subunit: heme binding subunit of
superoxide generating NADPH Treat with
interferon gamma Clarithromycin (macrolide)
ADR of metallic taste & GI
Codeine
ADR resp. depression, euphoria, &
constipation
Cyclobenzaprine
Structurally similar to TCAs w/
anticholinergic side ef fects used for relief
of muscle spasms May exacerbate
glaucoma
Naproxen
ADR of GI & renal (in elderly)
Caused by Trypanosoma cruzi parasite
passed in the feces of Reduviidae/kissing
bug Penetrates broken skin or intact
mucous membranes forming a
pseudocyst releasing inflammatory
infiltrates into myocytes; stains with
Giemsa & W right Romana sign occurs
when portal of entry is the conjunctiva or
eyelid May resulting in: Enlarged heart-
CHF, sudden cardiac arrest Enlarged
esophagus- dif ficulty swallowing Enlarged
colon- abdominal pain or constipation
Treat with benznidazole or nifurtimox
Monocytes
cell with half-moon shaped nucleus that
participates in phagocytosis
Chronic graft rejection
multifactorial but typically involves
arteriosclerosis HLA-B27
PAIR: Psoriasis Ankylosing spondylitis-
chronic synovitis destroying cartilage
typically in young men Inflammatory
bowel dz- Crohn's & UC Reactive
Arthritis-
Reactive Arthritis
Arthritis as a reaction to a bacterial
infection such as Campylobacter ,
Chlamydia, Salmonella, Shigella, or
Ureaplasma. Associated with
conjunctivitis & uveitis
Gaucher (T ype 1)
AR L ysosomal storage disease
Accumulation of sphingolipid
glucocerebroside Most common W rinkled
tissue paper I Cell disease
Failure of Golgi apparatus to
phosphorylate mannose 6-phosphate the
marker to export enzymes to lysosomes
resulting in accumulation of lysosomal
enzymes in serum
Nitroblue tetrazolium test
Aqualitative test to determine defects in
NADPH oxidase Negative: CGD Positive:
Acute Hepatitis, Mono
CGD (chronic granulomatous disease)
inability to produce NADPH oxidase;
susceptible to Cat + organisms; elevated
neutrophils w/ normal T cell Gp91 phox
subunit: heme binding subunit of
superoxide generating NADPH Treat with
interferon gamma Clarithromycin (macrolide)
ADR of metallic taste & GI
Codeine
ADR resp. depression, euphoria, &
constipation
Cyclobenzaprine
Structurally similar to TCAs w/
anticholinergic side ef fects used for relief
of muscle spasms May exacerbate
glaucoma
Naproxen
ADR of GI & renal (in elderly)
