BMT CERTIFICATION COURSE FULL SOLUTION PACK ACTUAL QUESTIONS AND ANSWERS WITH COMPLETE SOLUTION

BMT CERTIFICATION COURSE FULL SOLUTION PACK ACTUAL QUESTIONS AND ANSWERS WITH COMPLETE SOLUTION What does Red Bone marrow do Produces Hematopoietic Stem cells that create RBC, plt, and WBC found in long and flat bones Think: Red like red blood cells What does Yellow Bone Marrow do? Both Yellow marrow and fat cells produce stromal stem cells that produce fat, cartilage and bone Think yellow like fat Where are hematopoietic cells produced> in long bones during childhood and axial skeleton in adulthood What do Myeloid Progenitor cells mature into? Megakaryocytes (produce plts) erythrocytes --> RBC Mast Cells --> macrophages, myeloid dendritic cell Myeloblasts --.> WBC compoents What do Lymphoid Progenitor cells mature into? Small lymphocytes which differentiate into B-cells, T-cells and NK cells What organs are involved in the immune system? Bone Marrow Thymus (forms T-cells) Lymph Nodes Spleen (filter WBC, plts and other substances) Innate Immunity uses phagocytes that release inflammatory mediators and NK cells Acquired Immunity Response of either B-cells or T-cells Advantages of Syngenic (identical twin) Transplant No need for immunosupression Disadvantage to Syngentic Transplant No graft vs tumor effect Advantage to matched sibling/related transplant No potential stem cell contamination and access to cells Disadvantage to matched sibling/related transplant Only 25% of population has a sibling match Risk of GVHD Advantage of mismatched sibling/related transplant No potential stem cell contamination and access to cells