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  • Universiteit Antwerpen (UA)
  • Geneeskunde
  • Farmacologie
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samenvatting farmacologie

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8 pages
2022/2023 Written for academic year
Institution
Universiteit Antwerpen (UA)
Course
Farmacologie
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samenvatting van farmacodynamiek, farmacokinetiek, chemische transmissie & autonoom zenuwstelsel, lokale hormonen & ontsteking

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SAMENVATTING
FARMACOLGOGIE GUNS
o farmacokinetiek (concentratie tov tijd)
 Opname in dunne darm
 Distibutie in weefsels
o Farmacodynamiek (effect tov concentratie)




FARMACODYNAMIEK

o Conventionele geneesmiddelen: zeer klein, hoge affiniteit
 Aspirine, crestor
o Biologische geneesmiddelen: grotere moleculen, vaak IV toedienen
 Insuline, pembrolizomumab
o Aangrijpingspunten geneesmiddelen
 Niet specifiek
 fysisch-chemische werking
 Grote hoeveelheid nodig
 Bv: anticacide, bulklaxativa, osmotische diuretica, plasmavervangers
 Specifiek
 Receptoren
 Ion-kanalen
 Opnamesystemen
 Enzymen
 Gen therapie


SOORTEN SELECTIVITEIT
- Chemische selectiviteit
 (bv: verlies van 1 AZ zorgt
voor functie verlies eiwit)
- Biologische specificiteit
 bv: angiotensine II
receptoren enkel in

, bloedvaten en niet in gastrointestinaal stelsel worden geactiveert, anders zouden patiënt met
behandeling angio II constipatie
hebben

RECEPTOREN

o 4 soorten
1) Ligand-gated ion kanalen
2) G proteïne receptoren
3) Kinase-linked receptoren
4) Nuclear receptoren




G-EIWIT RECEPTOREN

o Muscarine receptoren
o Acetylcholine receptoren
o Vasculaire gladde
spiercellen
o Cardiomyocyten

Document information

Study
Geneeskunde
Uploaded on
May 7, 2024
Number of pages
8
Written in
2022/2023
Type
Summary
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  • farmacologie

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