Neuropharmacology Exam 2 || Questions and 100% Verified Answers.

Psychostimulants correct answers Drugs that exert their behavioral effects by augmenting the actin of the monoamine NTs, usually dopamine Cocaine Hydrochloride correct answers Form where the leaves are mashed and cocaine is extracted at 60-80% concentration as a paste that is then treated with hydrochloric acid to form the less potent, water soluble salt Way Cocaine Hydrochloride is absorbed correct answers Through the nasal mucosa OR intravenously when dissolved in water Crack Cocaine (or freebase) correct answers Cocaine that is not aqueous, but can be dissolved in alcohol, acetone or ether, and is prepared for smoking before being sold. Way crack cocaine is taken correct answers Inhalation after heating Dosage of crack correct answers Range of 250 milligrams to 1 gram Cocaine hydrochloride dosage correct answers About 25 miligrams if snorted in a line Absorption factors of Cocaine correct answers Where it comes in through: Mucosal membrane is not very absorbent Crack vaporized or smoked is rapid and complete Absorption of cocaine through mucosal membrane correct answers Poor because cocaine is a potent vasoconstrictor. 70% to 80% of the amount absorbed goes to the liver, so only about 20 to 30% goes to the brain Absorption of crack through vapor correct answers Rapid and complete, where effects begin in seconds and reach the peak at 5 minutes. 30-60 second delay from the drug traveling from the injection to the brain Why cocaine metabolism is fast correct answers There are enzymes for its depletion in the blood and the liver that metabolize it almost completely Butyrylcholinesterase correct answers Major enzyme for cocaine metabolism in humans Cocaine in the brain correct answers Still present enough for detection here for 8 or more hours after use. Cocaine in the urine correct answers Present for up to 12 hours