BB. RH SYSTEM Questions with 100% Correct Answers

What are the five major antigens called in the Rh blood group system? Which ones are they? - Correct Answer Rh antigens, D, C, c, E, and e How many antigens total have been identified as Rh antigens? - Correct Answer 57 Which Rh antigen typing is included in routine donor and patient typing and is the most antigenic of the 5 major antigens followed by c, E, C, and e? The others are considered when antibody screening is positive. - Correct Answer D antigen Which Rh antigen pairs are antithetical? - Correct Answer C/c and E/e A pair (and occasionally more than a pair) of antigens that are coded by different alleles of a single gene. - Correct Answer Antithetical antigens These are RBC transmembrane proteins that are made of 417 amino acids and loops across the RBC membrane 12 times. They are well developed at birth, only expressed on RBCs, exhibit dosage (C/c and E/e), and are enhanced by enzymes like Papain and bromelin. - Correct Answer Rh antigens How many amino acids do C and c Rh antigens differ by? - Correct Answer 4 How many amino acids do E and e Rh antigens differ by? - Correct Answer 1 Which genes are linked closely on chromosome 1? Which gene codes for D antigen? Which one codes for C, c, E, and e antigens? - Correct Answer RHD and RHCE, RHD, RHCE Most D-negative (Rh negative) phenotypes are the result of the deletion of which gene? - Correct Answer RHD Which gene is on chromosome 6 and codes for a glycoprotein that complexes with the Rh proteins? It is a coexpressor gene that must be present for the Rh antigens to be expressed. - Correct Answer RHAG Individuals with the D antigen on their RBCs are considered this. These people can receive RH + or - blood. - Correct Answer Rh positive Individuals who are missing the D antigen on their RBCs are considered this. They should only receive blood from other individuals of this type. These individuals that develop antibodies to D must be given ____ __________ blood. - Correct Answer Rh negative