NR 329 Exam 1 | Questions & 100% Correct Answers (Verified) | Latest Update | Grade A+

Loading dose : a large initial dose given to achieve a rapid minimum effective concentration in the plasma Used when immediate drug response is required Ex. Digoxin, Z-pack Narrow therapeutic window : easily toxic drug requires more drug monitoring check peak + trough levels ex. Dilantin (anticonvulsant), vancomycin, 2 | P a g e Lithium Protein Bound Drugs : Drugs that bind to protein (albumin) and become inactive... too large to leave the vascular system Affects drug distribution-- takes a long time for drug to unbind to protein ex. Warfarin Becomes problem when taking multiple protein binding drugs -- drugs can become more toxic and or less effective half-life : determines dosing time requires for the amt of drug in the body to decrease by 50% 3 | P a g e short half life-- means the drug needs to be taken more frequently to control the symptom