Lilleys Pharmacology for Canadian Health Care Practice Ch 55 Study Guide Rated A

Lilley's Pharmacology for Canadian Health Care
Practice Ch 55 Study Guide Rated A+

1). Hematopoiesis

 Ans: Formation of new blood cells
*Red blood cells (RBC)
*White blood cells (WBC)
*Platelets


2). Where are rbcs made?

 Ans: bone marrow


3). Immature rbcs are called

 Ans: reticulocytes


4). Life span of rbc

 Ans: 120 days


5). What are rbc made up of?

 Ans: More than 1/3 of a RBC is made of hemoglobin


6). Anemia types

 Ans: Maturation defects
*Cytoplasmic
*Nuclear

Excessive destruction of RBCs (hemolytic anemias)
*Intrinsic RBC abnormalities
*Extrinsic mechanisms


7). Cytoplasmic maturation anemias




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,  Ans: Occur as a result of reduced or abnormal hemoglobin synthesis


8). Nuclear maturation defects

 Ans: Occur because of defects in DNA or protein synthesis


9). Intrinsic factor

 Ans: A substance produced by the mucosa of the stomach and intestines that is
essential for the absorption of vitamin B12.


10). Extrinsic factor

 Ans: Vitamin B12


11). Both dna and protein require

 Ans: Vitamin B12 and B6 (folic acid) to be present in normal amounts for their proper
production


12). Epoetin alpha (eprex)

 Ans: -Biosynthetic form of the natural hormone erythropoietin
-Used for treatment of anemia associated with end -stage renal disease, chemotherapy,
induced anemia, and anemia associated with zidovudine therapy


13). Epoetin alpha is ineffective without...

 Ans: Adequate body iron stores and bone marrow function


14). Most patients receiving epoetin alpha need to also take what?

 Ans: Iron supplement


15). Longer acting form of epoetin alpha

 Ans: Darbepoetin (Aranesp)


16). Epoetin alpha contraindications



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