ONS/ONCC CHEMOTHERAPY/IMMUNOTHERAPY LESSON 9: PLANT ALKALOIDS Exam | Questions & 100% Correct Answers (Verified) | Latest Update | Grade A+

Common plant alkaloids Correct Answer: Etoposide Docetaxel Paclitaxel Vinblastine Vinorelbine Vinca Alkaloids Correct Answer: -e.g. Vincristine, Vinblastine, Vinorelbine -IV ONLY: NEVER intrathecal (DEATH!!) -If administered in a syringe, it must be clearly labeled with IV ONLY label -many guidelines urge diluting vincristine into mini IV drip bag and never use syringe to administer to prevent error Taxanes 2 Correct Answer: e.g. paclitaxel, cabazitaxel, docetaxel -IV -significant risk of HSR Paclitaxel Correct Answer: -requires solvent cremophor EL and ethanol vehicle for IV admin -must be stored in glass or polypropylene bottle b/c potential for cremophor to leach the plasticizer from PVC infusion bag -Infuse through polyethylene-lined admin sets through in-line filter w/ a microporous membrane -pretreat with corticosteroids and antihistamines to lower fatal reactions -do not rechallenge after severe HSR Cabazitaxel Correct Answer: -requires diluent polysorbate 80 for IV admin -must be stored in glass or polypropylene bottle; NOT PVC infusion bag -Infuse through polyethylene-lined admin sets through in-line filter w/ a microporous membrane Docetaxel Correct Answer: -non-PVC supplies -in line filter NOT required -increased risk of HSRs so give premed