PICORNAVIRUS RFOVIRUG
: Enteric Orphan Virus
Respiratory
-
ENTEROVIRUS
R : Human Get
ASTROVTRU S. Astro-star-shaped ROTAVERWS
HEPEVIRUS
POLJOVERU5
(saliva respiratory droplets)
·
: Fecal-oral
↳ :
·
·
High risk
fecal-oral
of more
(contamination
severe infection : 3ut trimester pregnancy patients with removed tonsils
, [GgA) R OTAVIRUS · J P.: I
.
days
,
·
·
Acid-stable-Virus
Replicates f 2 weeks) in
can
tonsils
travel
+
through
Peyer patches
Gf
of GST,
/Acidity of
Spread
Stomach)
via
blood/lymph to motor neurons of anterior howe causing :
ASTROVIRUS ·Entersvia Gotinfecting achreplicatingin tip ofvillus
·
Gastroenteritis Vomiting fever
damaging Villi upon release -sdabsorptio one
HUMAN ASTROVIRUS (1-8) ·Fecatoral (fomites Air-Jovea
, ,
Fatal watery DSARRHEA /#1 cause in children)-due
(recovery is d absorption /fluid accumulation) +
Polo-AsymmetricGesecking ParalysisUPARALVPOLOMYELGS) with
·
loss to 6 , ·
to NSP4 toxin
tosensory
mots
up
ORTHOHEPEVIRUS
·
ELSSA- Direct examination of antigens in 5500L
·
Enters via 6) and infects and replicates at seujenal cells
of antibodiessee
·
Aseptic meningitis -
fever neck pain/stiffness , skin rash, vomiting
,
. ·
Gastroenteritis-In children ,
↳ Diarrhea Vomiting Pausea
elderly immunocompromised patients
, ·
PCR Indirectexamination
Ti therapy
throatofstrollectalswebforPlastic meningitis-virus may
Isolated from P Oral Live attenuated
PARV
Kontamination) & Reoviruses Vaccine
· · :
protesat
HEPATTIS E VIRUS (HEV)
,
fecal-oral
,
GK , & T :
PCR from stool
sample.
·
be absent but cleaning agents (chlorine heat)
·
Lumbar Puncture
=
bleach , high
i
·
outbreaks sensitive to
↳ food/Water-bourne ,
·
T: Supportive :
Proper sanitation and hygeine
.. Saltvaccine tractivated VaccineTiniectionbones Get immesystem
only produce EgG antibi !
COLIVERUS
e.
·
9
·
Travels through GST (Acid Stable) to invade and replicate hepatocytes
EgA antibodies. HEPAT5 T55 -Similar to
en
produces EgG ·
hepatitis A but jaundice is more
pronounced
(high mortality rate)
ERYTH
complication Vaccine-associated paralys ↳ severe/suften onset hepatic failure pregnant
C DLORADO TICK FEVER VIRUS (REOVIRUS)
↳ In ware cases , may cause :
in women
CALCIVIRUS
↳ NEVER turns Chronic (like HAV)
ENTEROVERUS GECHOVERUSLay & COXSACKSEVERS
-EgMaeti-HAV-ACVinfection
Limited to Westere United States
·
Indirect examination of Antibodies by ELESA e
·
T: Wood tick (Dermacentor) + Blood transfusion
↳ COXSACKE A+ B PARVOVIRU
·
:HumanGetFeculoralKontamination F ey
:
acid stable Infection self limiting No specific treatment · . EC3day
myalgia petechial/maculopapular e
·
· are
. , ,
s ·
Grades nasad ca
affected Immune complex
NOROVIRUS
of ASEPTIC MENTNGGSS Children
ASPECTES
·
· -
Main cause most
Y
Sumel ele ·Erythemainfectio
⑮Pestumor areofEncephalitiseAseftwenigitizinChitter ye(special y
in
NOROVIRUS (NORWALK VIRUS) .T:Fecal-Ora (fomites ,
Air-Jovea ·
Hydrops fetalis -
at the back of mouth
·
Transient aplastic
AfHerpaugina-febrileillness
↳ Coxsackie with small red resies e ·
Enters via 6) and infects and replicates at jeujenal cells
PCR, Indirec
·
same as above rashes of palms and soles. Acute Gastroenteritis (# cause if non-bacterial) In all T:
- · -
age groups
↳ Coxsackie B /hepatitis/pancreatitis ↳ Watery explosive Diarrhea
Myocarditis/ pericarditis
- Pleuro Lynia/Bornholm's disease -
fever with extreme unilateral sharp pain in lower chest ·
Outbreaks in closed
, Nausea
communities Vuitingre centers, schools, cruise shis is
↳ 'numbered' Enteroviruses
·
ELSSA-Direct examination of antigens in 5500L
variety of
C3f show theaboveby wtowsDepending ou speciesa
a
tipeof antibodieson and
a Pcr Indirect examina
proteinso
· ·
Lumbar Puncture for Dexamining a septic meningitis
siz
·
T. Supportive hygeine
·
.
Pi
· Coxsackie A and B can also be isolated from throat of S
Supportive.
·. care .·P Good hygien e/sanitation
HEPATOVIRUS ↓s NAKED
-
fecal-oral Kontamination)
WHAV)
· .
HEPATT ES A VIRUS ↳ food/Water-bourne outbreaks
NAKED
· P.: . 3-6 Was 828 days)
Travels invaded e replicate hepatocytes
/AcidStable)to
·
through GS
hitren
Asymptomatic
+
subclinica
usually
·
· HEPATTSS 16 month) fever , fatigue, -
a jaundice Vin abults) , hepatomegaly , pain in right upper quadrate
↳ NEVER turns C hronic (Like HEV)
symposite
D
Within &- Months
↳ directexaminationof AntibodiesgrahetiHAVGVeufective
of Onset
&
·
recommended for travellers to endemic countieshe
tractivatedVaccineand
Bakarino
· P:
Water Purification (via chlorination bleaching , ,
UV radiation, etc)
RHINOVIRUS [
Nose : Now
of ENTEROVERUS
considered
SPECSES]
one
-
~33% due to airo
Respiratory Oveto
UR itslow temperature of
VIRUSES
R Human
RHSNOVERUS :.
·
labile : No GST]
RNA DNA -
-3 Lays
Binds (to SCAM-0) and replicates respiratory mucosa/epithelial cells of nasopharynx Llow Temp -330) :
· in
↑
Common cold' symptoms (#) cause) Rhinorrhea nasal congestion , cough sore/scratchy throat -
·
-
, ,
(sputum)
-
Nose/throat for PCR
.
· swab
-
·
T Supportive
: care ·
P : Infected should cover cough
55
- -
COLOR-CODED KEY : ↓ -
Positive sense
ENV
FAMILY
Negative
CORONAVIRUS
- -
sense
23
35 -
Single Stranded
ds-
& HELICAL
double stranded
GENUS L -
Linear genome
BACOreRate tNAVERWE. Respirator
· R .: Birds Buts ,
.
Small mannals
droplets direct/indirect contant
PECEE
circular genome
5 - -
/
2 34 days
o
Reservoir (2) Transmission (1) , Incubation Period Li e
-
: # -Segmented
5 (# of segments)
-NVELOPED
↑
.
· a l Cells of Wrest ·
PathogenesisVirulence factors
, genome
&
&
PCR Indirect Infections/diseases Replicates NUCLEUS
-
in
·
- antibodies - ·
·
Chest X-ray
-
Shows focal or diffuse inters titial patchy infiltrates ·
Diagnosis >
- -
Replicates in CYTOPLASM
covering cough Treatment (5) , Prevention/Prophylaxis (P)
C ve NAV. RNAvaccine
·
supporti .
C
⑬
Common Coll-causing O#2 cas e
↳ Nasal
Congestion ,
Thinorrhea , sore throat, cough ,
a febrile
Respiratory Syndrome (SAR3)
exidemic t from
Acute
· Severe
-
2003 e
ARS-CoV
Fever , , Headache ,
Malaise myalgias & non-productive (dry) as
teRespiratoryDistressSyndromeAs e
3A failure
-
premonia , hypoxia Respiratory ,
· ↓
I
.
Same as above -
-
Sardi Arabia from camels
MERS-CoV Middleast :
Respiratory Syndrome (MER5) -
2012 epidemic in
same as above
-
HELSCAL
RETROVIRUS POXVIR
LENTIVERUS
HUMAN IMMUNODEFSCIENCY
·
T : Parenteral -J V
Envelope ↳ NOT Spread by
. .
mosquito bloodtransfusion,setually (
Grug use
VIRUS 1 + 2
rishinWomentreceptiveGul ,Verticaltransmissionelira wine Respiratory droplets
(HEV) · . : Humans
R (immune cells fluids)
Ro ORTHOPOX
VARSOLA VIRUS /SM
COW POX : Contact with
·
Enters
Sprevia respiratorytract toinvad
j
,
·
surface glycoproteins-coded by ENV gene
receptors(Cos,CXC4) Small
pox-flu-like illness for 2-4 d
·
of host immune cells (macrophages dendritic cells, helper Fcells CD4" recee
· glyroproteinifVy4-bindto chemokine
to
skin and mucosal
,
↳ Lesions/blisters on
ICOSAHEDRAL
, Corecepter (CR5 required for cell entry
Surrounding Center (Capsid)-Coded by GAG gene
·
Protein 24 (p24) Capsid protein forming capsid
-
:
· PCRp Clinical examination .
. :
Hist
P Live-attenuated
At the center of Viron-coded by POL gene :
VACCINGA The virus use
&NAPolymeraserzyweCreverse
transcriptase) Viral SsRNA <Viru SAN
RNALependent
-
·
· referred Provious
Integrase
to as
MOLLUSCIP
enome-now
mediates naturation assembly of viral particles + inhibition of host
protein Synthesis
RHABDOVIRUS
·
L
3-STAGE DISEASE :
·ute Flutite illness worth MOLLUSCUM
FluiMeSue tourGericuLyuhaheropathy elurged tousee CONTA
J
2 - :
Acquired Immuno-Deficiency Syndrome (ASDS)
·
body throug
Enters
CD 4 count <200 or Aids-defining
symptoms (opportunistic infections)
3 i
Lesions (small copper-colored home-sha
DELTAVIRUS LYSSAVERUS
·
,
& Lymphatenopathy 4 Splenomegaly BEncephalitis 4 Meningitis 4 + any other secondary bacterial fungal viral infections
,
, , ·
Clinical examination
· AfDS dementia Complex + Myelopathy caused by HJV as it crosses blood-brain barrier via infected monocytes/macrophages
-
·
Confirmation via HE staining of Lesion
·
2-Step Liagnosis /Indirect examination of antibodies) :
↳ ELSSA screening for EgM and EgG antibodies (P24 antigen) but
may give false positive results.
: If
positive , then : animal foxe e
↳ Western
Blotting more -
specific test looking for antibodies
,
via
applying serum to paper with common antigens RABTES VIRUS :: Bite ofinfected (Bat Doy, cat, ,
DELTAVIRUS
screening blood donors safe
·: antivirotics at motor end plate and
replicate inside
t sex ·
Enters via world , invade motor neurons
Limiting Viral growth combination of 3 drugs needed for Highly Active Anti-Retroviral Therapy SHAART)
A Binkstothethnicotinicacetylcholine receptorsUsing e surfaceglycoproteins
:
is
a
,
↳ NRT5s Involeoside reverse
transcriptaseinhibitors) : Zidovudine /
zalcitabine ·
serve
↳ NNRTEs (non-nucleoside reverse
transcriptase inhibitors)
↳ Protease inhibitors :I ndinavir saquinavir , HEPATIT55D VIRUS 9ABSE3-rogressesasa fever migrates virus
headache fatigue tingling t numbness
s...
Maarido-inhibits Geit ·
T-
: Parenteral -J V
. .
drug use blood
,
transfusion , Sexually ,
Vertical transmission ·
Painful pharyngeal or
,
Inspiratory
spas ,
spasms
-
,
caused by Water
as Virus
(hydrophobia) or Greathing (aerophobial
Raltegravir-inhibits integrase Re quires CO-INFECTION (Previous or current) with hepatitis B virus to REPLICATE ↳ Dysphagia Foaming of mouth due to spasms + ↑ salivary production dif reaches salivary glands)
·
-
↳ HDV utilizes the HBV Lipoprotein envelope for assembly and transmission ·
At CNS : ENCEPHALST55 , Seizures flaccid Paralysis, Hallucinations Coma Death
, , ,
OURING hepatitisa infection
iftransmissionisLove
↳ SUPERINFECTION a
Microscopy of Grain biopsy revealing NEGRS BODSES evsinophilic cytoplasmic inclusions
PARAMYO
· -
Acceleratespatitis = Fulminant Hepaticore (ASAP) Vaccination
. =RabiesImmuneGlobulinChed-Passiveimmunizationnation
·
·
Acute dangerous Onset) e and
Indirectexamination(Actibodies)-Anti-HIV HDV can't replicate without i re Vaccinationofimals
· ·
Gomestic animals
· as from should be WASHED + STERLIZED As
E