NSG 251 Key Compulsory Exam Questions And Correct Answers

Rank speed of absorption: Po, IM, IV Po slowest, then IM, IV fastest Describe drug distribution in relation to protein binding Protein binding- Most drugs form a compound and bind with plasma proteins. Drug molecules bound to plasma proteins are pharmacologically inactive. Only the free or unbound portions of the drug acts on the cells. Protein binding allows for some of the drug to be stored and others to be released as needed. This gives the constant blood level and decreased risk for toxicity. High binding=high duration of action. First pass effect a phenomenon of drug metabolism whereby the concentration of a drug is greatly reduced before it reaches the systemic circulation. It is the fraction of drug lost during the process of absorption which is generally related to the liver and gut wall. Does liver failure affect drug metabolism? Liver failure does affect metabolism of drugs