ACE Inhibitors Nursing Pharmacology Exam | Questions & Answers (Graded A+)

ACE Inhibitors Nursing Pharmacology Exam | Questions & Answers (Graded A+) ACE - ANSWER - angiotensin-converting enzyme Medications end in PRIL - ANSWER - Examples: Captopril, Lisinopril, Ramipril, Quinapril, Benazepril Angiotensin-converting enzyme inhibitor (ACE inhibitors) drugs include: - ANSWER - Benazepril (Lotensin) Captopril (Capoten) Enalapril/Enalaprilat (Vasotec oral and injectable) Fosinopril (Monopril) Lisinopril (Zestril and Prinivil) Moexipril (Univasc) Perindopril (Aceon) Quinapril (Accupril) Ramipril (Altace) and Trandolapril (Mavik) How these drugs work? - ANSWER - They inhibit the RAAS (renin-angiotensin aldosterone system). Goal of the RAAS? - ANSWER - To manage our blood pressure by activating a substance that naturally occurs in our body called Angiotensin II. How it does this? - ANSWER - Low blood pressure occurs Kidneys release RENIN into circulation causes ANGIOTENSINOGEN (a protein created and released by the liver) to produce ANGIOTENSIN I then a substance called ANGIOTENSIN-CONVERTING ENZYME (ACE) converts Angiotensin I to ANGIOTENSIN II prevent the conversion of Angiotensin I to Angiotensin II - ANSWER - ACE Inhibitors - converts Angiotensin I to Angiotensin II and it inactivates bradykinin by breaking it down (note: inhibiting ACE will increase the amount of bradykinin) - ANSWER - ACE is an inflammatory substance that dilates vessels but increased amounts of it are thought to lead to the dry, persistent cough experienced with ACEI. If this is experienced and can't be tolerated by the patient, the physician may switch the patient to an angiotensin II receptor blocker (ARB). - ANSWER - Bradykinin Causes major vasoconstriction of the vessels (increases SVR and blood pressure) Trigger the release of ALDOSTERONE Causes the kidneys to keep water and sodium but excrete potassium. - ANSWER - Angiotensin II: