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Toxicology Real Exam with Questions Solved 100%
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What is the mechanism of toxicity of Amphotericin-B - causes renal arteriolar vasoconstriction which reduces GFR and renal blood flow leading to ischemic renal injury and uremia you have intramembranous ppores form which causes renal tubules to be more permeable, this allows excessive ions to be delivered to distal tubule and decreasing GFR (since they back up) antagonizing ADH impairs urine concentrating ability and leads to polyuria MOA of aminoglycosides? - nephorotoxic, ototoxic especially in cats
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