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Anti-Ulcer drugs help by: - -altering gastric pH by decreasing acid secretion -protecting the stomach wall lining by increasing mucosal protection -eradicating harmful bacteria Ex: H. Pylori What are the main pharmacologic categories of drugs we used to manage gastric acid secretion and the effects: - -antacids -H2 receptor antagonists -proton pump inhibitors (PPIs) -prostoglandin analogs -mucosal protectant sulcrafate (Carafate) What is the first OTC medication tried by patients with dyspepsia? - -Antacids --these are typically not effective for persistant GERD and PUD What are antacids? How do they work? - -organic salts -neutralize the hydrochloric acid in the stomach -raises the gastric pH above 4.0 What are the main side effects of antacids? - -diarrhea -constipation What are the different categories of antacids? - -calcium carbonate -sodium bicarbonate -aluminum based -magnesium based -aluminum hydroxide

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