PC 707 Final Exam Prep Drug Interactions Questions and Answers with complete

Grapefruit juice - Answer-CYP 450 inhibitor - Intake leads to increased pharmacologic effect of drugs Warfarin - Answer-Interacts with TMP-SMX, erythromycin, Flagyl, Diflucan = Increases INR (Increased bleeding and hemorrhaging) Tetracycline - Answer-- Do not take with milk products Clarithromycin - Answer-- Avoid mixing with lovastatin, simvastatin, and calcium channel blockers - when mixed with the statins listed, it is metabolized quickly - when mixed with calcium channel blockers, it can cause kidney injury TMP/SMX (Bactrim) - Answer-Interacts with Warfarin = Increased INR - Avoid mixing withACE inhibitors and ARBs Metronidazole (Flagyl) - Answer-Do not drink alcohol while taking or 24-48 hours after (this includes medications with alcohol) Cimetidine (Tagamet) - Answer-CYP 450 inhibitor MANY drug to drug interactions- Warfarin - Calcium Channel blockers - Metronidazole ACE inhibitors - Answer-Must be stopped before switching to an ARNI (36-48 hours) due to the risk of angioedema that can occur when these meds are combined with ARNIs - do not combine with ARBs