Immunotherapy Chemotherapy practice test with verified accurate expert solutions(2024 LATEST UPDATE)ALREADY GRADED A+(GUARANTEED SUCCESS)

Predictors of PDL1/PD1 inhibitor response Presence of tumor CD8 cell infiltration High cancer genome burden High levels of cancer PD-L1 expression (PD1 is on the cytotoxic T cell) Ipilimumab CTLA4 inhibitor Nivolumab PD-1 inhibitor Regorafenib VEGF inhibitor Bevacizumab Monoclonal antibody against VEGF-A. Inhibits angiogenesis. Pembrolizumab PD-1 inhibitor Atezolizumab PD-L1 inhibitor Avelumab PD-L1 inhibitor Durvalumab PD-L1 inhibitor Cemiplimab PD-1 inhibitor for SCC skin PARP inhibitors Inhibit ADP ribosylase 1. Niraparib 2. Olaparib 3. Rucaparib synthetic lethality with BRCA mutation Nucleoside analogues Cytarabine, Fludarabine, gemcitabine Affect the cell cycle during S Topoisomerase inhibitors Etoposide Doxorubicin- also anthracycline Teniposide Irinotecan Topotecan Taxanes MOA and examples inhibit the function of microtubules during M phase through hyperstabilization Paclitaxel and docetaxel Vinca Alkaloids MOA Inhibit tubulin polymerization, halting the cell and leading to cell death -- affect cells in G2/M phase Vinca Alkaloids Vincristine Vinblastine Vinorelbine Antimetabolites 5FU, capecitabine, hydroxyurea, MTX Affect S phase because of replication Antibiotics Bleomycin, dactinomycin, adriamycin and MMC Alkylating agents MOA Alkylates guanine at N7 position, causes DNA breakage & cross-linking Substitutes the alkyl group for H on DNA Not cell cycle specific - affects resting and dividing cells Alkylating agents Busulfan, Cyclophosphamide, ifosfamide,