Pharmacology for Nurses. A Pathophysiologic Approach Adams - Holland - Urban (Unit 1)
"Natural" Does Not Always Mean Safer - ◦ Some active chemicals are the same as in prescription and OTC medications ◦ Substituting alternative therapy for established medical treatment may prolong condition ** Oral Drugs Enter Hepatic Portal Circulation (First-Pass Effect) - 1. Drug is absorbed 2. Drug enters hepatic circulation, goes to liver 3. Drug is metabolized to inactive form 4. Drug conjugates and leaves liver 5. Drug is distributed to general circulation 6. Many drugs are rendered inactive by first-pass effec
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