NR 507 Advanced Pathophysiology Week 3 Quiz- Version 2

In some anemias, the erythrocytes are present in various sizes, which is referred to as anisocytosis. poikilocytosis. microcytosis. isocytosis. Additional descriptors of erythrocytes associated with some anemias include anisocytosis (assuming various sizes) or poikilocytosis (assuming various shapes) (Figure 26-1). What is the pathophysiologic process of aplastic anemia? Autoimmune disease against hematopoiesis by activated cytotoxic T cells Inherited genetic disorder with recessive X-linked transmission Malignancy of the bone marrow in which unregulated proliferation of erythrocytes crowd out other blood cells Autoimmune disease against hematopoiesis by activated immunoglobulins Most cases of AA result from an autoimmune disease directed against hematopoietic stem cells. Cytotoxic T cells (Tc cells) appear to be the main culprits. The body compensates for anemia by increasing rate and depth of breathing. capillary vasoconstriction. hemoglobin holds on to oxygen more firmly. kidneys release more erythropoietin. Tissue hypoxia creates additional demands and compensatory actions on the pulmonary and hematologic systems. The rate and depth of breathing increase in an attempt to increase the availability of oxygen. A woman complains of chronic gastritis, fatigue, weight loss, and tingling in her fingers. Laboratory findings show low hemoglobin and hematocrit levels, and a high mean corpuscular volume. These findings are consistent with anemia. aplastic iron deficiency folate deficiency pernicious Gastric atrophy commonly occurs in the presence of type A chronic gastritis and may be autoimmune. Autoantibodies against gastric parietal cells are frequently observed. When the hemoglobin level in the blood has decreased significantly (7 to 8 g/dl), the individual experiences the classic symptoms of anemia—weakness, fatigue, paresthesias of the feet and fingers, difficulty in walking, loss of appetite, abdominal pains, and weight loss. Symptoms of polycythemia vera are mainly the result of increased blood viscosity. destruction of erythrocytes. a decreased erythrocyte count. neurologic involvement. As the disease progresses many of the symptoms are related to the increased blood cellularity and viscosity.