NMTCB PET certification Review

NMTCB PET certification Review questions with correct answers GRADED A Rb-82 Genertaor Alert Level - 14L of eleute volume reached, or Sr-82 level 0.002uCi/mCi of Rb-82, or Sr-85 level 0.02uCi/mCi of Rb-82 Actions for Rb82 Generator Alert Level - Test after every 750 mL has passed through generator Stop using Rb-82 generator if - 17L of eleute volume reached, or 42 days post calibration date, or Sr82 levenis 0.01uCi/mCi of Rb82, or Sr85 level reaches 0.1uCi/mCi of Rb82 Cyclotron produced isotopes and half-life - C11, 20.3 min; N13 9.97 min; O15 2.03 min; F18, 109.7 min Advantages of negative ion cyclotrons - 1) less nuclear activation of cyl potion cavity and surroundings, 2) can self-focus beam of particles, 3) can irradiate 2 targets at once Isotopes produces by negative ion cyclotrons - C, N, O = metabolites Reaction for chemical labeling of F18-FDG - Nucleophilic substitution Chemical reaction of FDG - Electron rich group of atoms change place on molecule with a positively charged leaving group Precursor molecule for FDG - Mannose triflate Chem formula of FDG - 2-deoxy-2-[18F]fluoro-D-glucose. (Fludeoxyglucose F-18) Intermediate step in FDG synthesis - Alkaline hydrolysis of 4 acetyl groups by replacing with OH Size filter used after purification - 0.22 um FDA ref for PET pharma production - General chapter 823 FDG QA appearance - Colorless liquid FDG QA radiochemical identity - Thin-layer chromatography Rf value to reference standard FDG QARadionuclide identity - Half-life 105 and 115 minutes FDG QA bacterial endotoxins test - LAL (Limulus amebocyte lysate) 175 USP endotoxins units per max volume injection; endotoxins 17.5 EU FDG QC pH - Between 4.5 to 7.5 FDG QA Radiochemical purity - Thin-layered chromatography radioactive Rf should be not less than 90% of total radioactivity of chromatography plate FDG QC Radionuclideic purity - should be 99.5% of radionuclidie specified. tested using multichannel analyzer with peaks at 0.511 and 1.022 MeV