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Summary physiotherapeutic theory: Fatigue in MS

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Summary of the fatigue in MS lesson given by prof. F. Santinelli of the course physiotherapeutic theory. It is a summary of the powerpoint slides and additional items noted during the lesson. The slides were in English and my own notes are always in Dutch as much as possible. It is therefore a mix of the 2 languages because it is an English-language master. Everything is in dots, so no complete paragraphs

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December 17, 2023
Number of pages
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Written in
2023/2024
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Phys theory:MS: fatigue & fatiguability

Terminoly and definition

 Fatigue
- Vermeoidheid
- Fysiek en cognitief
 Fatiguability
- Vermoeibaarheid

 relationship between perceived fatigue and performance fatiguability in people with MS: a systematic review and
meta- analysis (bryan D. Loy et al)
- conclusion
 there is a significant relationship between perceived fatigue and fatiguability in MS, such that people
reporting elevated fatigue also are highly fatigable. The size of the relation is not large enough to
suggest fatigue ad fatiguability are the same construct, and both should continue to be assessed
independently
- correlatie tussen metingen= zeer lag
- meten ½= beide meten
 hebben ander mechanisme

 Kluger B.M., Krupp L.B., Enoka R.M. Fatigue and fatigability in neurologic illnesses: Proposal for a unified
taxonomy. Neurology . 2013
- Factors gerelateerd aan ziekte & sec aan andere factoren
 Sec= depressie,…




 Van Geel et al 2020!!!!!!
- Trait fatigue
 Describes…. Nieuwe ppt
- Fatigability is defined as the “magnitude or rate of
change in a performance criterion relative to a
reference value over a given time of task
performance or measure of mechanical output.”
- Activity induced state fatigue is turn is
charakterized by an acute an temporary change in
motor or cognitive performance as well as the
subjective expierence of wearness or exhaustion
that occur in the context of a specific motor or
cognitive task (behrens et al 2023)
- State fatigue= fatigability
- Fatiguability is test afhankelijk –> mechanisme
fatiguability

Nala Melis Pagina 1

, Phys theory:MS: fatigue & fatiguability

 Behrens artikel “distignuising between fatigue and fatiguability in MS” voor beschrijving MS??
 Saltatory conduction 100-300m/s




 Symptomen
- Afhnankelijk van regio hersenen aangedaan specifieke
symptomen krijgen
- Fatigue= vnl trait fatigue


 Fatigue
- A subjective lack of physical and/or mental energy that is perceived by the individual or caregiver to
interfere with usual and desired activities
- Nagaan met vragenlijsten
- Steeds gerelateerd aan beleving P

 Motor fatiguability
- Different levels of ICF




Prevalence
fatigue
 Prevalence and burden of MS-related fatigue: a systematic literature review (Oliva Ramirez et al., 2021)
- 54 studies +10 thousand people with multiple sclerosis
- 36,5%-78% of prevalence*
- Considering pediatric and adult MS*
- ↓ Quality of life
- Unemployment
- Economic burden
- Negative impact on work
- Kinderen kunnen ook al MS hebben




Nala Melis Pagina 2

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