Biochemistry Final Exam UNE CHEM 1005 (Weeks 9-15) Q’s & A’s Solved 100% Correct!!

Biochemistry Final Exam UNE CHEM 1005 (Weeks 9-15) Q’s & A’s Solved 100% Correct!! Control of Fatty Acid Synthesis vs. Oxidation When Insulin is HIGH -- fatty acid synthesis occurs When Glucagon is HIGH -- lipolysis, fatty acid B-oxidation, ketogenesis occur **These never happen at the same time! Lipolysis Process of releasing free fatty acids from triacylglycerols stored in the adipose IN THE FASTED STATE Steps of lipolysis 1) Hormone Sensitive Lipase: activated by glucagon and epinephrine TAGs are hydrolyzed into FFAs and glycerol (inhibited by insulin) 2) Long chain FFAs travel bound to albumin to peripheral tissues to be used as energy source 3) Glycerol travels to liver to be used as gluconeogenesis substrate 4) Acyl-CoA Synthetase: can reconvert FFAs to acyl-CoA to be used for re-esterification in the adipose (continuous cycle of lipolysis & re-esterification) Beta Oxidation Process of generating acetyl-CoA, NADH, and FADH2 from the oxidation of FFAs taken up by peripheral tissues (mostly liver & skel. muscle tissue). Happens in mitochondria. Long chain FFAs cannot cross the mito membrane, so a