BMTCN STUDY GUIDE QUESTIONS AND
ANSWERS
erythrocyte, platelets, neutrophil, basophil, eosinophil, monoblast, macrophage, monocyte -
answer Myeloid
pre- B cell, pre-t cell, plasma cell, natural killer cell, t lymphocyte - answer lymphoid
occurs naturally- phagocytes release inflammatory mediators - answer innate immunity
response of either b or t cells to antigens - answer acquired immunity
loss of cells power to divide and grow - answer senescence
reduction in size of thymus and function of immune cells - answer immunosenescence
myeloid - answer first responders
lymphoid- pathogen specific - answer second responders
identical twin, don't need immunosuppression, con- no graft vs tumor effect - answer syngeneic
-promoted by withdrawal of immunosuppressant therapy
-promoted by DLIs
-dec. in absence of acute gvhd
-higher rate of relapse - answer graft vs. tumor effect
, infusion of lymphocytes from donor given when there is relapsed disease. Attempt to create
GVT effect - answer DLI
- 70 %, - faster engraftment, no anesthesia risks, dec. likelihood of contamination by tumor, -
higher risk of gvhd, - but better gvt effect- so dosent make sense for SCD - answer PBSCT
filgrastim. a glycoprotein stimulates the production of stem cells by binding to certain cell
surface areas - answer G-CSF
sargramostim. lower stem cell yields. and inc adverse events. similar mechanism of action -
answer GM-CSF
chemo causes reduction in production of blood cells thus stimulating hematapoetic recovery.
-cyclophosphamide
-paclitaxel
-etoposide
-cytarabine
-improved mobilization
-more rapid engraftment
-reduced risk of tumor cell contamination - answer chemo induced mobilization
directly induce mobilization by working as antagonist between the chemokine stromal-derived-
factor- 1 and receptor CXCR4.
-Plerixafor
-often in combination with GCSF - answer chemokine antagonist mobilization
produces stem cells that create rbcs, whit bcs, and plts. found in long and flat bones - answer
red bone marrow
ANSWERS
erythrocyte, platelets, neutrophil, basophil, eosinophil, monoblast, macrophage, monocyte -
answer Myeloid
pre- B cell, pre-t cell, plasma cell, natural killer cell, t lymphocyte - answer lymphoid
occurs naturally- phagocytes release inflammatory mediators - answer innate immunity
response of either b or t cells to antigens - answer acquired immunity
loss of cells power to divide and grow - answer senescence
reduction in size of thymus and function of immune cells - answer immunosenescence
myeloid - answer first responders
lymphoid- pathogen specific - answer second responders
identical twin, don't need immunosuppression, con- no graft vs tumor effect - answer syngeneic
-promoted by withdrawal of immunosuppressant therapy
-promoted by DLIs
-dec. in absence of acute gvhd
-higher rate of relapse - answer graft vs. tumor effect
, infusion of lymphocytes from donor given when there is relapsed disease. Attempt to create
GVT effect - answer DLI
- 70 %, - faster engraftment, no anesthesia risks, dec. likelihood of contamination by tumor, -
higher risk of gvhd, - but better gvt effect- so dosent make sense for SCD - answer PBSCT
filgrastim. a glycoprotein stimulates the production of stem cells by binding to certain cell
surface areas - answer G-CSF
sargramostim. lower stem cell yields. and inc adverse events. similar mechanism of action -
answer GM-CSF
chemo causes reduction in production of blood cells thus stimulating hematapoetic recovery.
-cyclophosphamide
-paclitaxel
-etoposide
-cytarabine
-improved mobilization
-more rapid engraftment
-reduced risk of tumor cell contamination - answer chemo induced mobilization
directly induce mobilization by working as antagonist between the chemokine stromal-derived-
factor- 1 and receptor CXCR4.
-Plerixafor
-often in combination with GCSF - answer chemokine antagonist mobilization
produces stem cells that create rbcs, whit bcs, and plts. found in long and flat bones - answer
red bone marrow
