NR 546 WEEK 5 Table - Antidepressant Medications
Name Indication, starting dose, target symptoms, and affected neurotransmitters Half-life (T1/2) CYP450 enzyme Notes/Notable side effects/Precautions SSRIs Citalopram (Celexa) • Target symptoms • Depressed mood • Anxiety • Panic attacks, avoidant behavior, reexperiencing, hyperarousal • Sleep disturbance, insomnia and hypersomnia Indication • Depression • PMDD • OCD • Panic d/o • GAD • PTSD • Social anxiety d/o Neurotransmitter • Serotonin • Weak inhibitor of CYP450 2D6 Metabolized by CYPf450 3A4 and 2C19 Half-life 23-45 hour CYP450 • • Rare seizures, induction of mania, activation of suicidal ideation Sexual dysfunction • Decreased appetite, n/d, constipation, dry mouth • Dose dependent insomnia, sedation, agitation, tremors, headache,dizzy • Pt with bipolar or psychotic d/o may be more vulnerable to CNS-activating actions of SSRIs • Sweating • Bruising and rare bleeding • Rare hyponatremia • Syndrome of inappropriate antidiuretic hormone
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