NURS 180 - Pharmacology - Chapter 3 (solved)

Pharmacokinetics correct answers is the process of drug movement throughout the body necessary to achieve drug action. Four process are (1) absorption, (2) distribution, (3) metabolism, and (4) excretion/elimination Drug Absorption correct answers is the movement of the drug into the bloodstream after administration 80% of drugs are taken by mouth (enteral) correct answers Dissolution correct answers drug in solid form must disintegrate into small particles and combine with liquid to form a solution to be absorbed from the GI into the bloodstream. Excipients correct answers Fillers and inert substances, such as simple syrup, honey, vegetable gum are used in drug preparation to allow the drug to take on a particular size and shape and to enhance drug dissolution. Disinegration correct answers is the breakdown of an oral drug into smaller particles. Drugs are both disintegrated and absorbed fast in acidic fluids. correct answers Both the very young and older adults have less gastric acidity; therefore absorption is generally slower for enteral medication correct answers Enteric-Coated Drugs correct answers Resist disintegration in the gastric acid of the stomach, disintegration occurs once it reaches the alkaline environment of the small intestine. Should not be crushed because they alter place and time of absorption correct answers Enteric-Coated drugs Passive Transport correct answers occurs through two processes: diffusion and facilitated diffusion. Diffusion correct answers drugs move across the cell membrane from an area of higher concentration to one of lower concentration Diffusion concentration movement correct answers From high concentration to low concentration Facilitated Diffusion correct answers relies on a carrier protein to move the drug from an area of higher concentration to an area of lower concentration Facilitated Diffusion Concentration Movement correct answers Needs a protein to move from HIGH concentration to LOW concentration