NROS 310 exam 1 questions with correct answers

What are the main organs affected by cystic fibrosis? - Answer Lungs, any organ that has epithelial cells, mucus, and secretory system which requires regulation of that mucus Describe the main function of the CFTR protein and how it is regulated. - Answer responsible for regulating the proper flow of chloride and sodium (a component of salt) in and out of the cell membranes in the lungs and other organs. It is regulated by its cytosolic domains: two nucleotide binding domains (NBDs) and a regulatory (R) domain. Why does the most common CF mutation cause a loss of function? - Answer It disrupt the function of the chloride channels, preventing them from regulating the flow of chloride ions and water across cell membranes. Describe how a defect in the CFTR leads to the problems in cystic fibrosis. - Answer Cells that line the passageways of the lungs, pancreas, and other organs produce mucus that is unusually thick and sticky. Outline three ways to treat patients with Cystic Fibrosis. - Answer medicines to make the mucus in the lungs thinner and easier to cough up. medicines to widen the airways and reduce inflammation. special techniques and devices to help clear mucus from the lungs. What is cholera: what is it caused by and how does it affect the body? - Answer Ingestion of dirty water → results in dehydration.Over activation of cAMP by inhibition of G-subunit leading to outflux of Chlorine. This leads to dehydration.