Leik: Pharmacology questions with correct answers

First Pass Metabolism CORRECT ANSWER GI Tract ---> Portal Circulation ---> Liver --->Metabolized ---> Systemic Circulation 1st pass metabolism lowers the amount of drug available. If high first-pass effect, mostly becomes inactivated and cannot be used, these meds cannot be given orally. Example: Insulin Drug Metabolism CORRECT ANSWER The most active organ is the LIVER (Cytochrome P450 enzyme system) Others are Kidneys, GI Tract, Lungs Coumadin and Bactrim CORRECT ANSWER Sulfa drugs will interact with warfarin (increases the blood level) which results in: *Elevation of INR and Risk of Bleeding! Potent Inhibitors of the cytochrome P450 (CYP450) System *Responsible for a number of drug to drug interactions CORRECT ANSWER ■ Macrolides (erythromycin, clarithromycin, pediazole)