Advanced Pathopharmacology 2023

D027 – Advanced Pathopharmacology 2023 1. Celiac Disease a. Lining of the small intestine, intolerant of gluten. (avoid BROW) Barley, Rye, Oat, Wheat i. More pronounced in the duodenum and jejunum. b. Signs and Symptoms - abdominal pain/distention; diarrhea (pale, greasy, bulky, foul) i. Malnutrition complications - rickets, occult blood, anemia (early bleeds and/or bruises) ii. Hypomagnesemia and hypocalcemia = Irritability, tremors, convulsions, tetany, bone pain, osteomalacia c. Lab Value: IgA-tTg, total IgA, IgA-EMA, HLA-DQ2 or HLA-DQ8; IgG maybe too. d. IgA is associated with Celiac disease, diagnosis via endoscopy with small intestine biopsy 2. Sjogren’s Syndrome - Dry eyes and dry mouth a. Mostly in older women, primarily those with Rheumatoid arthritis or SLE b. Testing: SSA+ and SSB+ 3. Herbs a. Cinnamon - ↓ blood glucose, ↓ cholesterol, ↓ hypertension, ↓ risk for bleeding i. Adverse Effects - no breastfeeding, no DM drugs/anticoagulants/heart medications. b. Gingko Biloba - ↓ dementia, ↓ erectile dysfunction. ↑ bleeding, ↓ seizure threshold. c. Glucosamine - osteoarthritis d. Green Tea - lose weight, mental clarity. can cause hepatotoxicity. may ↓ the effects of warfarin. i. Avoid taking with vasodilators, stimulants, and psychoactive medications