Overdose Opioids Drug Abuse (Exam 2) Answered 100% Correct

What is E-FORCSE? - ANSWER-Database with history of all controlled substances prescribed to patient How do you prevent a morphine overdose? - ANSWER-Use lessphine I actually overdosed on anxiety pills a few minutes ago - ANSWER-I'm not too worried about it What are 4 common accidental overdoses? - ANSWER-1. Acetaminophen 2. Alcohol 3. Iron 4. Other prescription drugs What are five common drugs of abuse? (Class and drugs) - ANSWER-1. Stimulants- Amphetamines, Cocaine, MDMA (ecstasy), synthetics (bath salts) 2. Hallucinogens- Marijuana and synthetic cannabinoids, LSD 3. Alcohol 4. Heroin 5. Prescription Drugs- Opioids, Benzodiazepines What drug overdose is most commonly due to accidental ingestion? - ANSWER-Acetaminophen Acetaminophen is metabolized into leading a hepatotoxic metabolite ______________________________________. What happens to this with therapeutic doses compared to overdose? - ANSWER-N-acetyl-p-benzoquinone imine, NAPQI - After therapeutic doses, the liver generates glutathione, which detoxifies NAPQI - In overdose, glutathione is depleted, leaving the metabolite to produce toxicity How do you confirm acetaminophen toxicity? Is there an antidote? If so, when is it most effective? - ANSWER-Confirm with a blood test Antidote: N-Acetylcysteine - Most effective when administered within 8-10 hours of ingestion Accidental ingestion of iron can have toxic effects with as little as ___________ of elemental iron, and doses of ____________ may be lethal. - ANSWER-As little as 20mg/kg 60mg/kg may be lethal!