AUA Med 1-- Biochemistry—Organelles Questions With Complete Solutions

What is glycosylation? correct answer: most common type of post-translational modification, produces glycoproteins what is added to the side chain of Asn( N) (Asparagine) ? correct answer: Oligosaccharide, therefore N- linked glycosylation why N-Linked glycosylation ? correct answer: prevent protein from aggregating and aids their binding chaperons what are chaperons ? correct answer: Proteins that assist in folding of new polypeptides, make sure it folds properly folds before progressing to the golgi apparatus why polypeptides may misfold ? correct answer: due to gene mutations, error in transcriptions, translation why chaperons are called heat shock proteins (HSP) ? correct answer: expressed at high temp to prevent protein denaturation or misfolding what happens when a protein does not fold properly ? correct answer: are polyubiquitinated and degraded by the proteasome what is the Smooth ER ? correct answer: making lipids , hormones also works in drug detoxification, muscle relaxation , glycogen metabolism what is stored in the Smooth ER ? correct answer: calcium What is the golgi apparatus? correct answer: a series of stacked flat membranous sacs called cisternae held in place by microtubules from where the cis-golgi network recieves the protein ? correct answer: from the rER in COP II coated vesicles