Maryville University Pharmacology NURS -615 Exam 2 How does carbamazepine work? - ✔✔Works by decreasing nerve impulses that cause seizures a nd pain How often should carbamazepine lab values be monitored? What labs? - ✔✔CBC q 3 -4 months What anti -seizure med auto induces metabolism? - ✔✔Carbamazepine What medication decreases the production of RBCs, WBCs, and platelets? - ✔✔Carbamazepine What is carbamazepine half -life? - ✔✔Single dose: 30 hours Multiple dose: 15 hours What is a great risk of seizure potential while taking anti -seizure medications? - ✔✔Stopping the medication abruptly. What type of medication is topiramate (Topamax)? - ✔✔Anti-seizure med What does topiramate cause? - ✔✔Electrolyte imbalance -- hyperchl oremic metabolic acidosis What are adverse effects of topiramate? - ✔✔Weight loss, high temperature, and inability to sweat What medication affects Lamictal? - ✔✔OCPs decrease the effects of this drug, so the dose must be doubled Can valproate (Depakote ) be used during pregnancy? - ✔✔It is a known teratogen. If needed, must be used after 1st trimester. What must be ruled out in patients before starting an anti -depressant? - ✔✔hypothyroidism Anti-depressant that is to be used with caution in cardiac pat ients due to behaving like class 1 anti -
arrythmics? - ✔✔TCAs TCA side effects are mainly of what type? - ✔✔Anti-cholinergic What is a first -line antidepressant in children? - ✔✔fluoxetine (Prozac) How do you discontinue an SSRI? - ✔✔Taper by reducing th e dose by 50% for 3 -4 days When are MAOIs effective? - ✔✔In atypical depression or Parkinson's Why are MAOIs reserved for last line of treatment? - ✔✔Lethal drug interactions and food interactions How long before starting a new antidepressant after MAOI s? - ✔✔At least 2 weeks to clear it from system What are high tyramine foods and when are they contraindicated? - ✔✔Fermented foods; aged cheese, wine alcohol Contraindicated with MAOI use Important drug interaction and side effect with MAOIs? - ✔✔Avoid other serotonin drugs and watch for hypertensive crisis What anti -depressant may have sleep issues if taken at night? - ✔✔fluoxetine (Prozac) (SSRI) How do SSRIs work? - ✔✔They block the re uptake of serotonin at the synaptic cleft so there is more serotonin around
arrythmics? - ✔✔TCAs TCA side effects are mainly of what type? - ✔✔Anti-cholinergic What is a first -line antidepressant in children? - ✔✔fluoxetine (Prozac) How do you discontinue an SSRI? - ✔✔Taper by reducing th e dose by 50% for 3 -4 days When are MAOIs effective? - ✔✔In atypical depression or Parkinson's Why are MAOIs reserved for last line of treatment? - ✔✔Lethal drug interactions and food interactions How long before starting a new antidepressant after MAOI s? - ✔✔At least 2 weeks to clear it from system What are high tyramine foods and when are they contraindicated? - ✔✔Fermented foods; aged cheese, wine alcohol Contraindicated with MAOI use Important drug interaction and side effect with MAOIs? - ✔✔Avoid other serotonin drugs and watch for hypertensive crisis What anti -depressant may have sleep issues if taken at night? - ✔✔fluoxetine (Prozac) (SSRI) How do SSRIs work? - ✔✔They block the re uptake of serotonin at the synaptic cleft so there is more serotonin around
