Neurotransmitter Table * To be completed throughout course and submitted in Week 8* Neuro transmitter Receptor Subtype Location/Function/Effects

Neurotransmitter Table * To be completed throughout course and submitted in Week 8* Neuro transmitter Receptor Subtype Location/Function/Effects /symptoms of excess or deficit if applicable Distribution (ie: CNS/PNS, GI, vascular) Drug classes that target this neurotransmitter or receptor Specific medications that target this neurotransmitter or receptor Glutamate AMPA α-Amino-3-hydroxy-5- methyl-4- isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) mediate the majority of fast excitatory synaptic transmission in the brain. AMPA receptors are abundant and widely distributed in the central nervous system. Hippocampus, outer layer of the cortex, basal ganglia, olfactory regions, lateral septum, and amygdala of the CNS are all enriched with GluA1, GluA2, and GluA3 subunits. CNS AMPA Receptor Antagonists Perampanel MNDA N-methyl-D-aspartate (NMDA) receptors represent one of the ligand-gated non-selective ionotropic glutamate receptors (iGluRs), which CNS NMDA receptors are found in both synaptic and extrasynaptic NDMA Glutamate Antagonist NDMA Glutamate AntagonistMemantine Phencyclidine Ketamine Dextromethorphan Dextromethadone are present in high density within the hippocampus and the cerebral cortex N-methyl-D-aspartate (NMDA) receptors, a family of L-glutamate receptors, play an important role in learning and memory, and are critical for spatial memory demonstrated deterioration in NMDA receptor subunit expression and function with advancing age locations on neurons. NMDA receptors also can be found on neurons in early stages prior to synaptogenesis, where they may be involved in migration and differentiation. Extrasynaptic NMDA receptors typically are associated with contacts with adjacent processes such as axons and glia GABA GABA a Limbic system GABAa is considered in fast synaptic inhibition. GABAa receptors are located throughout the central nervous system Benzodiazepines Neuroactive Steroids Zolpidem Zaleplon Zopiclone Eszopiclone Allepregnanolone Serotonin 5HT 5HT 1a 5HT1A receptors are located on GABA interneurons in the prefrontal cortex 5HT1A receptors can promote the release of CNS partial 5-HT1A-R agonists buspirone, gepirone, and tandospirone other neurotransmitters. 5HT1A receptors are always inhibitory, but they are very frequently localized upon postsynaptic GABA neurons, which means that the net downstream effect in this case is actually excitatory Excess Psychosis mood imbalance anxiety 5HT 1B 5HT1B receptors are inhibitory and can specifically inhibit neurotransmitter release from norepinephrine, dopamine, histamine, and acetylcholine neurons when these receptors are localized upon presynaptic nerve terminals of these neurons Imbalance causes Depression CNS Serotonin 1b Receptor Agonists Almotriptan Zolmitriptan Sumatriptan Naratriptan Rizatriptan Frovatriptan Eletriptan 5HT 1d 5-hydroxytryptamine (serotonin) receptor 1D, also known as HTR1D, is a 5-HT receptor, but also denotes the human gene encoding it. 5-HT1D acts on the central nervous system, and affects CNS Serotonin 5-HT1D Receptor Antagonists Antipsychotics Antipsychotics Ziprasidone Paliperidone Clozapine Aripiprazole Yohimbine Risperidone locomotion and anxiety. It also induces vasoconstriction in the brain. Serotonin 5-HT1D receptors, previously known as 5-HT1Dα receptors, are located primarily in the basal ganglia, hippocampus, cortex, spinal cord and vascular smooth muscle cells. 5-HT1D receptors are thought to be involved in neuropsychiatric disorders such as depression. 5ht 1e Function-unknown Serotonin 5-ht1E receptors are primarily located in the frontal cortex, caudate putamen, claustrum, hippocampus, and amygdala. CNS 5HT 1F The 5-HT1F receptor is found on terminals and cell bodies of trigeminal ganglion neurons and can modulate the release of CGRP from these nerves. CNS SEROTONIN 5-HT1F AGONISTS Lasmiditan Reyvow 5HT 2A 5HT2A receptors can both promote and inhibit the release of other neurotransmitters. Imbalance cause Mood CNS Serotonin 5-HT2A Receptor Antagonists Methysergide An ergot alkaloid used for the prophylaxis of migraine and cluster headaches. Mirtazapine A tetracyclic antidepressant used in the treatment