APHON Principles of Chemo and Biotherapy, Top Questions and answers, 100% Accurate. Verified.

APHON Principles of Chemo and Biotherapy, Top Questions and answers, 100% Accurate. Verified. Biotherapy - Targeted anticancer agents also known as biological response modifiers (BRM) Tyrosine kinase inhibitors (TKIs) are what class - Biotherapy Monoclonal antibodies (MoAbs) are what class - Biotherapy Define pharmacokinetics - Study of drug absorption, metabolism, and excretion Define pharmacodynamics - The concentration of the drug in the body and how it produces a response Define adjuvant chemotherapy - The use of chemo after another type of therapy, such as surgery, to treat residual disease or undetectable metastasis. Define neoadjuvant chemotherapy - When chemo is used preoperatively to decrease tumor burden in order to make it easier to remove the tumor surgically. Define sanctuary sites - Sites within the body where tumor cells sequester and are not easily reached by chemo such as the CNS What normal cells are most often effected by chemotherapy - Hematopoietic, mucosal (mouth & GI), hair follicles Why use chemotherapy - To prevent cancer cells from dividing, metastasizing, and ultimately causing the death of the patient Cure - To permanently eradicate the cancer Control - To extend the length & QOL when cure is not feasible or realistic Palliation - Minimize pain and suffering during end of life Resting phase of cell cycle - Gap 0 - cells not dividing Postmitotic phase - Gap 1 - enzymes needed for DNA synthesis are produced, protein and RNA synthesis takes place (18 Hours) Synthesis (S) Phase - Cellular DNA duplicated (20 hours) Premitotic phase - Gap 2 - both protein and RNA synthesis occur, precursors of mitotic spindle are produced. Shortest phase Mitosis (M) Phase - Cell division occurs in 4-step phase (prophase, metaphase, anaphase, telophase) 1 Hour 5 stages of reproduction of cells - Resting, Postmitotic, synthesis, premitotic, mitosis Cell Cycle time - The amount of time it takes a cell to move from one mitotic episode to another. Cell-cycle-specific agents - Those drugs that work only when cells are in a specific phase of the cell cycle. Doubling time - The time required for a tumor mass to reach a certain size or double in size.