CPPS 325 FINAL EXAM questions with correct answers
What are the 5 well-known enzyme-linked cell surface receptors? Answer 1. Receptor Guanylyl Cyclase: produces cGMP 2. RTK: phosphorylate tyrosine residues leading to association of signalling molecules and cascade 3. TK Associated Receptors: associate with proteins having TK activity 4. Receptor Tyrosine Phosphates: Removes phosphate on tyrosine residues 5. Receptor Serine/Threonine Kinases: phosphorylate specific Serine/Threonine residues on IC signalling molecules How are RTK and TK Associated Receptors different? Answer RTK phosphorylate tyrosine while associated receptors bind/find proteins with TK activity to initiate the cascade of signalling. What is the reciprocal of RTK? Answer Receptor Tyrosine Phosphatases. They take the phosphate off the tyrosine residues to inactivate signalling cascades. Ex. Transforming GF Beta superfamily of receptors, cell type dependent. What is the major mechanism for receptor signal transduction? Answer Tyrosine kinase phosphorylation RTK vs. Serine/Threonine Phosphorylation ? Answer Tyrosine
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