NSG 532 Exam 4 Actual Questions With Complete Solutions

NSG 532 Exam 4 Actual Questions With Complete Solutions epitope - ANSWER antigen determinant expressed by a non self can you have more than one epitope? - ANSWER yes and there are specific immune responses for each hapten - ANSWER non self, non immunogenic epitope that when added to a carrier protein produces an immune response- such as poison ivy antigens - ANSWER non self foreign material that evokes a weak or no immune response and the body makes no memory for- for example the common cold, each time we get it it's like the first time immunogens - ANSWER non self antigen that provokes a very strong immune response and memory- it's foreign, complex, big what are the two primary immune organs and what is the main function of each? - ANSWER thymus- T cell differentiation and Bone marrow- B cell differentiation where does b cell differentiation occur - ANSWER bone marrow only where does t cell differentiation occur - ANSWER bone marrow and thymus corticomedullary junction of thymus - ANSWER this is where you have double negative cells and only CD3 is positive, it enters from the bone marrow into the thymus cortex of thymus - ANSWER this is the early phase of t cell differentiation where the cell gains three markers to become double positive, CD3/4/8 and TCR are positive medulla of thymus - ANSWER when the cell goes from double positive to single positive EITHER CD8 or CD4 is positive, negative selection occurs which protects against autoimmunity what happens in B cell differentiation - ANSWER hematopoeitic stem cells have CD3+ and add a B cell receptor - lymphoblastic stem cells - pro/pre B lymphocytes - B cells in lymph nodes - plasma cells - antibodies what type of cell becomes a plasma cell - ANSWER B lymphocyte what type of immune cell is characterized by antigen specificity - ANSWER B lymphocytes where does the actual interaction between self and non self occur within the immune system? - ANSWER secondary immune organs- lymph nodes, peyers patches (ileum), tonsils, appendix