Maryville University Pharm Exam 2 Questions With Complete Solutions

What blood values should be monitored with carbamazepine (Tegretol)? P. 236-237 correct answer: CBC for agranulosytosis (leukopenia/ neutropenia), BMP, and liver function tests, monitored at baseline prior to administration and followed throughout treatment What is the pharmacodynamics of carbamazepine (Tegretol)? P. 235 correct answer: Carbamazepine depresses transmission in the nucleus ventralis anterior of the thalamus. This area is associated with the spread of seizure discharge. Exact mechanism of action not known but may work by slowing sodium influx to the cortical neurons thus slowing the spread of abnormal neuron activity. What should families be taught regarding the monitoring of seizure activity? correct answer: Seizure triggers, when to contact the physician, how to take medications properly and that medication needs may change with patient growth (kids), need for monitoring blood levels, signs of adverse drug reactions What electrolyte imbalance is noted with the administration of topiramate (Topamax)? P. 239 correct answer: Topiramate is a carbonic anhydrase inhibitor used for seizures and migraines. This can increase bicarb loss (via the kidneys) which decreases serum bicarb levels. The result is hyperchloremic metabolic acidosis.