PEBC Questions And Answers
Time it takes for amount of drug to fall to half of its value, constant in first order kinetics (majority of drugs) - Answer- Half-life (T1/2) Inducers of Cytochrome P450 (CYP450) (4) - Answer- Barbiturates Phenytoin Carbamazepine Rifampin Inhibitors of CYP450 - Answer- Cimetidine Ketoconazole Erythromycin Isoniazid Grapefruit Their MOA utilizes intracellular receptors: - Answer- Thyroid and steroid hormones This compound's MOA utilizes transmembrane receptors: - Answer- Insulin Antidote used for organophosphate/anticholinesterase - Answer- Atropine, pralidoxime (2-PAM) Antidote used for acetaminophen (APAP) toxicity - Answer- N-acetylcysteine Antidote used for heparin toxicity - Answer- Protamine Sulfate Antidote used for warfarin toxicity - Answer- Vitamin K and Fresh frozen plasma (FFP) Antidote for tissue plasminogen activator (t-PA), streptokinase - Answer- Aminocaproic acid Antidote used for opioid toxicity - Answer- Naloxone (IV), naltrexone (PO) Antidote used for benzodiazepine toxicity - Answer- Flumazenil Interaction with this drug requires dose reduction of 6-MP(6-mercaptopurine) - Answer- Allopurinol May protect against doxorubicin cardio-toxicity by chelating iron - Answer- Dexrazoxane Blows DNA (breaks DNA strands), limiting SE is pulmonary fibrosis - Answer- Bleomycin Binds tubuli
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