CBG.27 T and B Cells

CBG.27 T and B Cell Development
Objectives:

 Clonal proliferation
 B cells
o B cell development: B cell receptors
 Antibodies
 T cells
o T cell development: T cell receptors
o Fate of T cells
o Roles of CD4+ and CD8+ T cells



Clonal proliferation




2nd lymphoid organs

(Image source: Kuby Immunology 7th edition, page 15) (Owen, Punt & Stranford, 2013)

Binding of 1 lymphocyte receptor to 1 antigen  clonal proliferation of stem cells (clonal selection &
expansion driven by antigen)

Deletion: Process of eliminating T or B cells that have too high a specificity OR specific to “self” molecules
for antigens (after they are made)

(i) Each lymphocyte bears 1 type of receptor with a unique specificity
(ii) Binding to lymphocyte receptor to specific antigen  activate lymphocyte
(iii) Activated lymphocyte starts to differentiate  daughter lymphocytes/effector cells have
similar receptors
(iv) Lymphocytes specific to “self” molecules are deleted  absent from mature lymphocytes
repertoire