PHARM: Chapter 23 - Drugs Used to Treat HTN

3 Factors responsible for BP - - Cardiac Output (primary determinant of systolic BP) - Blood Volume - Peripheral Vascular Resistance (primary determinant of diastolic pressure) 3 principles relating to cardiac output - - Preload (impact of venous system) - Afterload (impact of arterial system) - Contractility (pumping action of heart) A direct renin inhibitor aliskiren (Tekturna) is not as effective in which populations? - - African Americans - Older adults A patient has been prescribed amlodipine (Norvasc) for treatment of hypertension. The nurse contacts the prescriber after discovering that the patient is also taking which drug? a. Ciprofloxacin (Cipro) b. Digoxin (Lanoxin) c. Milk of Magnesia d. Tetracycline (Sumycin) - b. Digoxin (Lanoxin) Amlodipine is a calcium channel blocker that may increase serum levels of digoxin. This patient will need to be carefully monitored for signs of digitalis toxicity. Ciprofloxacin (a fluoroquinolone antibiotic), Milk of magnesia (an antacid), and tetracycline (an antibiotic) do not interact with the calcium channel blocker amlodipine.