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Samenvatting hoofdstuk 1-3 Infectieziekten

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Hoofdstuk 1 tot 3 van de cursus Infectieziekten (zelfde tekst als in cursus maar dan in puntjes). Voor het vak Microbiologie en infectieziekten

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INFECTIEZIEKTEN



prof. dr. W. PEETERMANS

prof. dr. P. DE MUNTER




ACADEMIEJAAR 2020 - 2021

, 2



HOOFDSTUK 1

Pathofysiologie van infectieziekten.

DEFINITIES
- Infectieziekte = klinisch waarneembare toestand van schade of verandering in normale
fysiologie van gastheer
o Gaat gepaard met ontstekingsreactie (inflammatie)
o Veroorzaakt door besmetting met ziekmakend micro-organisme
- Besmetting gaat infectie vooraf → maar leidt niet per se tot infectie
o Soms enkel kolonisatie of dragerschap


PATHOFYSIOLOGIE
- Infectie ontstaat wanneer pathogeen vermogen van micro-organisme de overhand heeft
op afweersysteem van gastheer
- Interactie tussen micro-organisme & gastheer: weergeven in piramide van infectieziekten

THERAPIE


farmacokinetiek farmacodynamica


farmacodynamica



metabolisatie resistentie
en excretie/
interacties en
toxiciteit


GASTHEER COMMENSAAL
micro-organisme


gastheer resistentie kolonisatie resistentie
weerstand




virulentie PATHOGEEN kolonisatie
micro-organisme


Klinisch beeld: bepaald door ziekmakend vermogen van het micro-organisme en de infectiefocus
enerzijds en de inflammatoire reactie van de gastheer anderzijds

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