NR 283 Concept Review Exam 3 patho (Best for Revision)

Hematology RBC-function- Erythrocytes (or RBC’s) are the most abundant cell type in the body  Its primary job is tissue oxygenation  The cell has 2 unique properties: o A biconcave shape which makes it optimal for gas transport o The capacity to be reversible deformed. The cells can change shape to make it through all the different size vessels in the body  Erythrocytes have a lifespan of 120 days  Hemoglobin is the oxygen carrying protein of the erythrocyte that gives RBC’s their color  Each erythrocyte has over 300 hemoglobin molecules; 1 HGB can carry 4 oxygen molecules Erythropoiesis is the creation of erythrocytes from the bone marrow Erythropoietin-produced, what does it do- Erythropoietin is the hormone that stimulates the production of erythrocytes. o It is produced by the kidneys Epogen (epoetin alpha) is indicated for the treatment of anemia due to chronic kidney disease (CKD), including patients on dialysis and not on dialysis to decrease the need for red blood cell (RBC) transfusion Anemias-types/ S/S of each- Anemia is a decreased total number of erythrocytes or a decrease in the quality or quantity of hemoglobin  Causes of anemia are: o Impaired erythrocyte production o Acute or chronic blood loss o An increase in the destruction of erythrocytes o A combination of all 3 Types of anemia NR 283 CONCEPT REVIEW EXAMS 3  pernicious anemia -It is caused by a