NSG6005 Week 2 Quiz Bank Ch: 2, 5, 6, 10, 13
Chapter 2: Review of Basic Principles of Pharmacology
____ 1. A patient’s nutritional intake and lab work reflects hypoalbuminemia. This is critical to prescribing because: A. Distribution of drugs to target tissue may be affected ____ 2. Drugs that have a significant first-pass effect: C. Are rapidly metabolized by the liver and may have little if any desired action ____ 3. The route of excretion of a volatile drug will likely be: B. The lungs ____ 4. Medroxyprogesterone (Depo Provera) is prescribed IM to create a storage reservoir of the drug. Storage reservoirs: C. Increase the length of time a drug is available and active ____ 5. The NP chooses to give cephalexin every 8 hours based on knowledge of the drug’s: B. Biological half-life ____ 6. Azithromycin dosing requires the first day’s dose be twice those of the other 4 days of the prescription. This is considered a loading dose. A loading dose : A. Rapidly achieves drug levels in the therapeutic range ____ 7. The point in time on the drug concentration curve that indicates the first sign of a therapeutic effect is the: C. Onset of action ____ 8. Phenytoin requires a trough level be drawn. Peak and trough levels are done: D. To determine if a drug is in the therapeutic range ____ 9. A laboratory result indicates the peak level for a drug is above the minimum toxic concentration. This means that the: B. Concentration will produce an adverse response NSG6005 Week 2 Quiz Bank Ch: 2, 5, 6, 10, 13
____ 10. Drugs that are receptor agonists may demonstrate what property? C. Desensitization or down-regulation with continuous use ____ 11. Drugs that are receptor antagonists, such as beta blockers, may cause: B. An exaggerated response if abruptly discontinued ____ 12. Factors that affect gastric drug absorption include: C. Lipid solubility of the drug ____ 13. Drugs administered via intravenous (IV) route: B. Begin distribution into the body immediately ____ 14. When a medication is added to a regimen for a synergistic effect, the combined effect of the drugs is: B. Greater than the sum of the effects of each drug individually ____ 15. Which of the following statements about bioavailability is true? A. Bioavailability issues are especially important for drugs with narrow therapeutic ranges or sustained release mechanisms. ____ 16. Which of the following statements about the major distribution barriers (blood-brain or fetal placental) is true? B. The blood-brain barrier slows the entry of many drugs into and from brain cells. ____ 17. Drugs are metabolized mainly by the liver via Phase I or Phase II reactions. The purpose of both of these types of reactions is to: C. Change drug molecules to a form that an excretory organ can excrete ____ 18. Once they have been metabolized by the liver, the metabolites may be: A. More active than the parent drug B. Less active than the parent drug C. Totally “deactivated” so that they are excreted without any effect D. All of the above
Chapter 2: Review of Basic Principles of Pharmacology
____ 1. A patient’s nutritional intake and lab work reflects hypoalbuminemia. This is critical to prescribing because: A. Distribution of drugs to target tissue may be affected ____ 2. Drugs that have a significant first-pass effect: C. Are rapidly metabolized by the liver and may have little if any desired action ____ 3. The route of excretion of a volatile drug will likely be: B. The lungs ____ 4. Medroxyprogesterone (Depo Provera) is prescribed IM to create a storage reservoir of the drug. Storage reservoirs: C. Increase the length of time a drug is available and active ____ 5. The NP chooses to give cephalexin every 8 hours based on knowledge of the drug’s: B. Biological half-life ____ 6. Azithromycin dosing requires the first day’s dose be twice those of the other 4 days of the prescription. This is considered a loading dose. A loading dose : A. Rapidly achieves drug levels in the therapeutic range ____ 7. The point in time on the drug concentration curve that indicates the first sign of a therapeutic effect is the: C. Onset of action ____ 8. Phenytoin requires a trough level be drawn. Peak and trough levels are done: D. To determine if a drug is in the therapeutic range ____ 9. A laboratory result indicates the peak level for a drug is above the minimum toxic concentration. This means that the: B. Concentration will produce an adverse response NSG6005 Week 2 Quiz Bank Ch: 2, 5, 6, 10, 13
____ 10. Drugs that are receptor agonists may demonstrate what property? C. Desensitization or down-regulation with continuous use ____ 11. Drugs that are receptor antagonists, such as beta blockers, may cause: B. An exaggerated response if abruptly discontinued ____ 12. Factors that affect gastric drug absorption include: C. Lipid solubility of the drug ____ 13. Drugs administered via intravenous (IV) route: B. Begin distribution into the body immediately ____ 14. When a medication is added to a regimen for a synergistic effect, the combined effect of the drugs is: B. Greater than the sum of the effects of each drug individually ____ 15. Which of the following statements about bioavailability is true? A. Bioavailability issues are especially important for drugs with narrow therapeutic ranges or sustained release mechanisms. ____ 16. Which of the following statements about the major distribution barriers (blood-brain or fetal placental) is true? B. The blood-brain barrier slows the entry of many drugs into and from brain cells. ____ 17. Drugs are metabolized mainly by the liver via Phase I or Phase II reactions. The purpose of both of these types of reactions is to: C. Change drug molecules to a form that an excretory organ can excrete ____ 18. Once they have been metabolized by the liver, the metabolites may be: A. More active than the parent drug B. Less active than the parent drug C. Totally “deactivated” so that they are excreted without any effect D. All of the above
