Module 5 Exam- Requires Respondus LockDown Browser

Module 5 Exam- Requires Respondus LockDown Browser Due No due date Points 100 Questions 40 Time Limit 120 Minutes Requires Respondus LockDown Browser Attempt History Attempt Time Score LATEST Attempt 1 82 minutes 93.33 out of 100 Score for this quiz: 93.33 out of 100 Submitted Jul 23 at 10:37pm This attempt took 82 minutes. Ques 3 / 3 pts tion 1 Multiple Choice: Which of the following is concerned with the treatment of disease and suffering? therapeutics Correct! pharmaceutics pharmacology pharmacotherapies Q 3 / 3 pts uestion 2 Multiple Choice: 7/24/2020 Module 5 Exam- Requires Respondus LockDown Browser: Essential Biology II with Lab- Correll Vaccines, hormones, and insulin are examples of: traditional drug therapies biologics Correct! natural alternative therapies Ques 2 / 2 pts tion 3 Multiple Choice: The goal of the preclinical phase is to determine which drugs are: not safe Correct! safe efficacious Ques 0 / 3 pts tion 4 Multiple Choice: The clinical investigation stage of drug development is important for determining each of the following except: adverse effects improvement of condition orrect Answer worsening of other conditions 7/24/2020 Module 5 Exam- Requires Respondus LockDown Browser: Essential Biology II with Lab- Correll gathering data from clinical trials ou Answered Ques 3 / 3 pts tion 5 Multiple Choice: During the NDA process, if there is a concern regarding safety or effectiveness data, what will occur? the process is permanently halted the process is continued developers are given the opportunity for remediations Correct! the process must begin again at pre-clinical studies Ques 2 / 2 pts tion 6 Multiple Choice: During the post-marketing phase, focus remains on _____within the general population. adverse events Correct! profit margin toxicity none of the above 7/24/2020 Module 5 Exam- Requires Respondus LockDown Browser: Essential Biology II with Lab- Correll Ques 2 / 2 pts tion 7 Multiple Choice: The therapeutic classification of a drug that targets bacteria is called: antacid antibiotic Correct! antifungal none of the above Ques 3 / 3 pts tion 8 Multiple Choice: Mechanism of action refers to how a drug: affects a body system treats a condition produces a desired effect Correct! none of the above Q 2 / 2 pts uestion 9 Multiple Choice: 7/24/2020 Module 5 Exam- Requires Respondus LockDown Browser: Essential Biology II with Lab- Correll Classifying drugs by their potential for abuse is referred to as: schedule Correct! mechanism of action desired effect none of the above Ques 2 / 2 pts tion 10 Multiple Choice: Psychological dependency is characterized by: intense desire Correct! physiological withdraw symptoms no symptomology all of the above Ques 3 / 3 pts tion 11 Multiple Choice: Safety categories pertain to: children pregnancy Correct! 7/24/2020 Module 5 Exam- Requires Respondus LockDown Browser: Essential Biology II with Lab- Correll adults elderly Ques 2 / 2 pts tion 12 Your Answer: Fill in the blank. The critical factor that removes selection bias from the clinical trial process is_______________. randomization randomization Ques 2 / 2 pts tion 13 Multiple Choice: Placing healthier patients into the experimental group because you expect them to tolerate a drug with mild side effects is called: randomization group selection selection bias Correct! 7/24/2020 Module 5 Exam- Requires Respondus LockDown Browser: Essential Biology II with Lab- Correll Ques 3 / 3 pts tion 14 Clinical trial protocols contain which of the following? (select all that apply) length of study Correct! inclusion criteria Correct! outcomes to be measured Correct! results assessments to be conducted Correct! potential harms Correct! Ques 2 / 2 pts tion 15 Multiple Choice: During a clinical trial, a placebo is often administered to the: control group Correct! experimental group both groups Ques 2 / 2 pts tion 16 Multiple Choice: 7/24/2020 Module 5 Exam- Requires Respondus LockDown Browser: Essential Biology II with Lab- Correll Well defined parameters narrow a participant pool to an intentionally designed: general population study population Correct! representative population Ques 3 / 3 pts tion 17 Multiple Choice: For one to appropriately power a study, what metric is of concern? participant age participant gender sample size Correct! Ques 3 / 3 pts tion 18 Your Answer: Fill in the blank. Participants are informed of potential harms, benefits, and voluntary status through a process called _______________ . informed concent 7/24/2020 Module 5 Exam- Requires Respondus LockDown Browser: Essential Biology II with Lab- Correll informed consent Ques 2 / 2 pts tion 19 Your Answer: Fill in the blank. Participants that are effectively randomized so that bias is removed reflects the ____________ validity of a study. internal internal Ques 2 / 2 pts tion 20 Your Answer: Fill in the blank. When the results of clinical trial are generalizable from the study population to the broader general population, it reflects _____________ validity. external external Q 3 / 3 pts uestion 21 7/24/2020 Module 5 Exam- Requires Respondus LockDown Browser: Essential Biology II with Lab- Correll Multiple Choice: With simple randomization, the risk of imbalance increases if you have: a small sample Correct! a large sample size equal sample sizes Q 3 / 3 pts uestion 22 Multiple Choice: Blocking ensures an allocation ratio of: control: experimental 1:1 Correct! 2:1 Ques 2 / 2 pts tion 23 True or False. Stratification is a method used to analyze results according to subgroups. True Correct! False 7/24/2020 Module 5 Exam- Requires Respondus LockDown Browser: Essential Biology II with Lab- Correll Ques 3 / 3 pts tion 24 Match each term with the correct definition. single-blind study researchers are aware of Correct! double-blind study both researchers and par Correct! open-label trial both researchers and par Correct! Ques 2 / 2 pts tion 25 Multiple Choice: Open label studies are useful when: comparing new drug to old drug Correct! comparing reductions in side effects assessing improvement of disease state Q 3 / 3 pts uestion 26 By which of the following are Phase I drug trials characterized? (select all that apply): 7/24/2020 Module 5 Exam- Requires Respondus LockDown Browser: Essential Biology II with Lab- Correll small scale Correct! Follows NDA approval focused on pharmacokinetics Correct! follows preclinical trials Correct! large scale healthy volunteers Correct! determines MTD Correct! Ques 1.33 / 2 pts tion 27 Phase II drug trials are characterized by which of the following? (select all that apply): MTD MED Correct! efficacy Correct! therapeutic index orrect Answer Ques 3 / 3 pts tion 28 Your Answer: (short answer) How do the terms efficacy and effectiveness differ? 7/24/2020 Module 5 Exam- Requires Respondus LockDown Browser: Essential Biology II with Lab- Correll Efficacy is the ability of the drug produces the desired outcome in the labratory and effectiveness is the ability to generate the desired result in the general population of users Efficacy is how a drug performs in controlled laboratory conditions. Effectiveness is how the drug performs (reduces symptomology) in patients with the disease; it’s real world conditions. Ques 3 / 3 pts tion 29 True or False. Phase IV differs from Phase III in that Phase IV involves blocking and randomization to assess adverse events. True False Correct! Ques 3 / 3 pts tion 30 Your Answer: (short answer) What three principles characterize the Belmont Report? respect for persons - given concent/autonomy (needs to be mentally competent) beneficence - researches work to minimize harm and maximize benefit for the participants in teh research justice - benefits& burdens distributed equally 7/24/2020 Module 5 Exam- Requires Respondus LockDown Browser: Essential Biology II with Lab- Correll Beneficence, justice, respect for persons. Ques 2 / 2 pts tion 31 Multiple Choice: Coercing or threating a person to continue participating a study they no longer wish to continue enrollment is a violation of: respect for persons Correct! beneficence justice Ques 2 / 2 pts tion 32 True or False. Drugs are absorbed in the stomach and transported actively or passively. True False Correct! Q 0 / 3 pts uestion 33 True or False. Lipid solubility, molecular size, duration of action, and toxicity are examples of physiological properties that can influence 7/24/2020 Module 5 Exam- Requires Respondus LockDown Browser: Essential Biology II with Lab- Correll distribution of a drug. True ou Answered False orrect Answer Ques 2 / 2 pts tion 34 Multiple Choice: The blood brain barrier is an example of challenges to drug: absorption distribution Correct! metabolism excretion Ques 3 / 3 pts tion 35 Your Answer: Fill in the blank. Chemical changes made to a drug during metabolism is called _______________. biotransformation biotransformation 7/24/2020 Module 5 Exam- Requires Respondus LockDown Browser: Essential Biology II with Lab- Correll Ques 3 / 3 pts tion 36 True or False. Prodrugs remain inactive until absorption in the small intestine. True False Correct! Ques 3 / 3 pts tion 37 Your Answer: (short answer) Why is the hepatic, first pass effect considered a protective adaption? The bodies mechainsm to protect itself from toxins ingested from the enviorment going into general circulation of the body. Tp-=hey will first be processed in teh liver. Because things we ingest go to the liver for processing/deactivation before having the opportunity to make it to general circulation and reach the heart or brain. Therefore, poison, microorganisms and toxins can be inactivated to some degree. Q 2 / 2 pts uestion 38 Multiple Choice: 7/24/2020 Module 5 Exam- Requires Respondus LockDown Browser: Essential Biology II with Lab- Correll While the kidneys are the primary organs of drug excretion, elimination in feces can also occur because of: biotransformation first pass effect enterohepatic recirculation Correct! metabolism Ques 2 / 2 pts tion 39 Your Answer: Fill in the blank. _____________is the amount of time it takes for a drug’s initial concentration to be reduced by ½. half life Half-life Ques 2 / 2 pts tion 40 Multiple Choice: A drug that binds to a receptor and facilitates a response has____________action. agonistic Correct! 7/24/2020 Module 5 Exam- Requires Respondus LockDown Browser: Essential Biology II with Lab- Correll antagonistic competitive