Module_6_Notes

Module 6 Study Guide: Cardiovascular & Hematologic
Friday, May 7, 2021 4:58 PM



LIPOPROTEINS
- High-density (HDL) = "Good"
- Low-density (LDL) = "Bad"
Nonpharmacological Interventions for Hyperlipidemia
- Lifestyle changes
○ Routine exercise
○ Smoking cessation
- Dietary changes
○ Reduce saturated fats
○ 30% or less fat in caloric intake
○ 300 mg/day or less of cholesterol

HMG-COA REDUCTASE INHIBITORS (STATINS)
- Decreases LDLs
- Increases HDLs
- Side Effects
○ GI distress
○ Constipation
○ Muscle cramps
○ Fatigue
○ Hepatotoxic
○ Myopathy
▪ Risk for rhabdomyolysis (death of muscle fibers which them releases into the blood)
▪ Monitor CK (creatine kinase)
- Interactions
○ Grapefruit juice (inhibits metabolism)
○ Erythromycin, ketoconazole, amiodarone
- Nursing Interventions
○ Monitor blood lipid levels (LDL, HDL, Triglycerides)
○ Monitor liver labs
▪ Baseline, 12 weeks, Q6 months
- Education
○ May take 2-3 weeks to have therapeutic effect
○ Report signs of liver dysfunction
○ Report muscles aches, pain, and tenderness
○ Do not take while pregnant or lactating
○ Take in evening with meal (especially lovastatin)
Lovastati
n
Atorvastatin
Simvastatin
Pravastatin
Rosuvastatin
Fluvastatin

BILE-ACID SEQUESTRIANTS
- Action
○ Reduce LDL by binding with bile-acids in the intestine
○ Forms insoluble complexes with bile salts (increasing bile loss in stool)
- Side Effects
○ Constipation
This study source was downloaded by 100000823822032 from CourseHero.com on 11-04-2021 12:17:18 GMT -05:00


https://www.coursehero.com/file/95668213/Module-6-Notespdf/

, ○ Flatulence




This study source was downloaded by 100000823822032 from CourseHero.com on 11-04-2021 12:17:18 GMT -05:00


https://www.coursehero.com/file/95668213/Module-6-Notespdf/