REMEDIATION
, ANTICOAGULANT
SHEPARINS
- Therapeutic uses: stroke; PE; DVT; prophylaxis for post-op venous thrombosis; treatment of DIC
- Heparin toxicity: admin PROTAMINE slowly IV no faster than 20 mg/min or 50 mg in 10 min; do
not exceed 100 mg in 2hr; prevent protamine toxicity
- Hemorrhage secondary to heparin toxicity: monitor vitals; observe for bleeding (increased HR;
decreased BP, bruising, petechiae, hematomas, black tarry stools); monitor aPTT (keep value 1.5
– 2 x baseline); stop heparin admin
- Epidural/spinal hematoma risk
- Monitor platelet count throughout treatment; stop heparin for platelet count < 100,000
LMW HEPARINS
- Therapeutic uses: DVT prevention and treatment; PE; prevent complications of angina; non-Q
wave MI; STEMI
- Enoxaparin
- Hemorrhage: monitor vitals; monitor platelet count; observe for bleeding; avoid aspirin
ACTIVATED FACTOR XA INHIBITOR
- Therapeutic uses: DVT and PE prevention postop; acute DVT or PE treatment in conjunction w/
warfarin
- Fondaparinux
- Hemorrhage: monitor vitals; monitor platelet count; monitor for bleeding; avoid aspirin
CONTRAINDICATIONS
- Thrombocytopenia
- Use during/following surgeries of eyes/brain/spinal cord/lumbar puncture/regional anesthesia
- Use caution in clients w/ hemophilia; increased capillary permeability; dissecting aneurysm,
PUD, severe HTN, hepatic/kidney disease, threatened abortion
INTERACTIONS
- Increased risk of bleeding w/ antiplatelet agents: ASPIRIN; NSAIDS
- Increased risk of bleeding w/ RESVERATROL; SAW PALMETTO; GARLIC; GINGER; GLUCOSAMINE;
GINKGO BILOBA
NURSING ADMIN
- Must be given via SUBQ injection or IV infusion
- Rotate sites
- Monitor for indications of bleeding
- Use electric razor
- Use soft toothbrush
VITAMIN K INHIBITORS (COUMARINS)
WARFARIN