Ibuprofen
BASICS: DOSAGE:
• 1 Analgesic - Non-Steroidal Anti • 200-600mg t.d.s.
Inflammatory Drug (NSAID) • Usually 200-400mg each dose
• POM and GSL • Maximum dose 2.4g daily
• Tablets or capsules
• NOT ALLOWED IN PREGNANCY
SIDE EFFECTS: CONTRAINDICATIONS:
• GI symptoms - nausea, vomiting, • Asthma
diarrhoea, constipation, stomach ulcers
• Pregnancy
• Headache
• Hx of GI bleeding or stomach ulcers
• Hypersensitivity reaction
• Coagulation disorders
INTERACTIONS: • Severe hepatic, renal or heart failure
• Anti-hypertensives - NSAID reduce effect
• Mifepristone
• Aspirin
PHARMACODYNAMICS: FETAL/BREASTFEEDING RISK:
• Absorbed from the GI tract - peak plasma • Inhibition of prostaglandin synthesis may
conc. 1-2 hours after administration adversely affect the pregnancy and/or
embryo/foetal development.
• Metabolised by the liver and excreted via • Studies suggest an increased risk of
the kidneys as metabolites miscarriage and of cardiac malformation and
gastroschisis after the use of a prostaglandin
• Half life = 2 hours synthesis inhibitor in early pregnancy.
• Inhibits the enzyme cyclo-oxygenase • NSAIDS present in breastmilk in low
which = reduction in prostaglandin concentrations - not known to cause harm
but manufactures advise not using
synthesis
BASICS: DOSAGE:
• 1 Analgesic - Non-Steroidal Anti • 200-600mg t.d.s.
Inflammatory Drug (NSAID) • Usually 200-400mg each dose
• POM and GSL • Maximum dose 2.4g daily
• Tablets or capsules
• NOT ALLOWED IN PREGNANCY
SIDE EFFECTS: CONTRAINDICATIONS:
• GI symptoms - nausea, vomiting, • Asthma
diarrhoea, constipation, stomach ulcers
• Pregnancy
• Headache
• Hx of GI bleeding or stomach ulcers
• Hypersensitivity reaction
• Coagulation disorders
INTERACTIONS: • Severe hepatic, renal or heart failure
• Anti-hypertensives - NSAID reduce effect
• Mifepristone
• Aspirin
PHARMACODYNAMICS: FETAL/BREASTFEEDING RISK:
• Absorbed from the GI tract - peak plasma • Inhibition of prostaglandin synthesis may
conc. 1-2 hours after administration adversely affect the pregnancy and/or
embryo/foetal development.
• Metabolised by the liver and excreted via • Studies suggest an increased risk of
the kidneys as metabolites miscarriage and of cardiac malformation and
gastroschisis after the use of a prostaglandin
• Half life = 2 hours synthesis inhibitor in early pregnancy.
• Inhibits the enzyme cyclo-oxygenase • NSAIDS present in breastmilk in low
which = reduction in prostaglandin concentrations - not known to cause harm
but manufactures advise not using
synthesis
