Summary NR 566 wk 4 Study Guide

NR 566 wk 4 Study Guide Chapter 25: Drugs Used in Treating Inflammatory Processes Gout medications Drugs: Anti-gout agents: allopurinol (Zyloprim), colchicine, and febuxostat (Uloric) Uricosuric agents: probenecid (Benemid) and sulfinpyrazone (Anturane) o Peak incidence 70 to 79 years old, more common in men than women o Gout in women occurs exclusively post-menopausal and is associated with HTN, renal insufficiency, and diuretics o Gout Syndrome: Caused by an alteration in purine metabolism: end product is uric acid o Hyperuricemia and deposition of urate crystals in various tissues o Four phases: asymptomatic hyperuricemia, acute gouty arthritis, inter-critical gout, and chronic tophaceous gout o Those with asymptomatic hyperuricemia do not require treatment (diet and lifestyle changes) o Acute gout is characterized by sudden onset of pain, erythema, limited ROM, and swelling of the involved joint  50% of cases involve the first metatarsal joint of the great toe o Key elements in Tx include management of the acute pain and use of antigout and uricosuric agents o Pain: NSAIDS and corticosteroids