Question 1.
Resources
ANSWER
nccn.org cancer.org
Question 2.
LESSON 1: Cell cycle
ANSWER
g1- increase in size s- dna replicated g2- cell enlarge and ready to divide m phase- 2 hours
Question 3.
mitosis
ANSWER
4 stages, prophase, metaphase, anaphase, telophase -chemo targets certain points in the process
Question 4.
apoptosis
ANSWER
programmed cell death
Question 5.
hematopoiesis
ANSWER
formation of blood cells & how cells differentiate -myeloid: pre cells mature into RBCs, platelets and WBCs -lymphoid: pre cellsmature into WBCS
Question 6.
Principles of Biotherapy: p51-95 immunology
ANSWER
-defense against foreign organisms, homeostasis (destroy aged cells), surveillance
Question 7.
immune responses
ANSWER
innate: primary line of defense, non specific, no memory adaptive: secondary line of defence with specific memry
, Question 8.
cytokines
ANSWER
-effect growth and differentiation of WBC -interferons, tumor necrosis factors, growth factos and interleukins -small protein molecules released by cells
throughout body providing comunication between cells of the immune system -regular antiboddy production and function of b cells
Question 9.
vaccines for cancer prevention
ANSWER
-hep B prevents hepatitis and hepatocellular carcinoma -hpv vaccine
Question 10.
filgrastim aka neupogen
ANSWER
SC or IV to derease infection in patients with neutropenic fever associated with myelosuppressive anticancer treatments for nonmyeloid malignancies
Question 11.
tbo-filgramstim/ pegfilgrastim
ANSWER
reduce duration of neutroenia in patients with non myeloid malignancies
Question 12.
palifermin
ANSWER
IV to dec incidence of oral mucositis in patients with hem malignanies before BMT
Question 13.
sargramostim
ANSWER
aka leukine - patients with AML following chemo to shorten neutrophil recovery and reduce incidence of infection
Question 14.
IFN gamma
ANSWER
reduce frequency and severity o infections related to granulomatous disease
Question 15.
aldeleukin
ANSWER
treat renal cell carcinoma and metastatic melanoma