UTA NURS 5334 Advanced Pharmacology for Nurse
Practitioners: Practice Test 1 (Units 1-7) - Questions with
Correct Answers
100 questions
1. The FDA MedWatch program is used to:
A. Order medications
B. Set drug prices
C. Prescribe controlled substances
D. Report serious adverse drug events
Correct Answer: D. Report serious adverse drug events
Rationale: Safety reporting.
2. Codeine requires conversion by CYP2D6 to:
A. Hydrocodone
B. Morphine
C. Oxycodone
D. Tramadol
Correct Answer: B. Morphine
Rationale: Ultra-rapid metabolizers risk toxicity.
3. The blood-brain barrier limits:
A. All lipophilic drugs
B. Entry of many hydrophilic and large molecules into the CNS
C. Oxygen
D. Glucose only
Correct Answer: B. Entry of many hydrophilic and large molecules into the CNS
Rationale: Protection.
4. Highly protein-bound drugs may interact because:
A. They are inactive
B. They are excreted faster
C. They can displace each other, increasing free drug levels
D. They cannot be absorbed
Correct Answer: C. They can displace each other, increasing free drug levels
Rationale: Displacement.
5. The first-pass effect refers to:
A. Hepatic metabolism of an oral drug before it reaches systemic circulation
B. Renal excretion
C. Distribution to fat
D. Protein binding
Correct Answer: A. Hepatic metabolism of an oral drug before it reaches systemic circulation
Rationale: Reduces bioavailability.
6. An agonist is a drug that:
A. Blocks a receptor
B. Has no affinity
C. Binds to a receptor and activates it
D. Only binds enzymes
Correct Answer: C. Binds to a receptor and activates it
Rationale: Activation.
,7. Adherence can be improved by:
A. Simplifying regimens, education and addressing cost barriers
B. Increasing pill burden
C. Avoiding explanations
D. Prescribing more drugs
Correct Answer: A. Simplifying regimens, education and addressing cost barriers
Rationale: Patient-centered.
8. A loading dose is used to:
A. Reduce side effects
B. Prolong half-life
C. Avoid metabolism
D. Rapidly achieve therapeutic concentrations for drugs with long half-lives
Correct Answer: D. Rapidly achieve therapeutic concentrations for drugs with long half-lives
Rationale: e.g., amiodarone.
9. Food generally affects drug absorption by:
A. Having no effect
B. Altering gastric emptying, pH and binding
C. Always increasing absorption
D. Always blocking absorption
Correct Answer: B. Altering gastric emptying, pH and binding
Rationale: Instructions matter.
10. The 'start low, go slow' principle is especially important in:
A. Healthy young adults
B. Athletes
C. Adolescents only
D. Older adults
Correct Answer: D. Older adults
Rationale: Geriatric prescribing.
11. Chelation interactions occur when:
A. Drugs increase absorption
B. Drugs are metabolized
C. Drugs are excreted
D. Tetracyclines or fluoroquinolones bind calcium, iron or magnesium, reducing absorption
Correct Answer: D. Tetracyclines or fluoroquinolones bind calcium, iron or magnesium,
reducing absorption
Rationale: Separate doses.
12. The volume of distribution describes:
A. The extent a drug distributes into body tissues versus plasma
B. Bioavailability
C. Excretion rate
D. Half-life only
Correct Answer: A. The extent a drug distributes into body tissues versus plasma
Rationale: Vd.
, 13. A partial agonist such as buprenorphine:
A. Produces maximal effect
B. Has no effect
C. Is a pure antagonist
D. Produces a submaximal effect and can block full agonists
Correct Answer: D. Produces a submaximal effect and can block full agonists
Rationale: Ceiling effect.
14. Drugs with a narrow therapeutic index include:
A. Amoxicillin
B. Loratadine
C. Warfarin, digoxin, lithium, phenytoin and theophylline
D. Acetaminophen at normal dose
Correct Answer: C. Warfarin, digoxin, lithium, phenytoin and theophylline
Rationale: Monitor levels.
15. Patients with CYP2C19 poor metabolizer status may have reduced effectiveness of:
A. Clopidogrel
B. Aspirin
C. Warfarin
D. Heparin
Correct Answer: A. Clopidogrel
Rationale: Prodrug activation.
16. Benzodiazepines in older adults increase the risk of:
A. Falls, fractures, cognitive impairment and delirium
B. Hypertension
C. Hyperglycemia
D. Weight loss
Correct Answer: A. Falls, fractures, cognitive impairment and delirium
Rationale: Beers.
17. Deprescribing involves:
A. Adding drugs
B. Never changing medications
C. Doubling doses
D. Systematically reducing or stopping medications that may no longer be beneficial
Correct Answer: D. Systematically reducing or stopping medications that may no longer be
beneficial
Rationale: Medication review.
18. Neonates have immature hepatic enzymes, which can:
A. Speed metabolism
B. Prolong drug half-lives
C. Increase renal excretion
D. Have no effect
Correct Answer: B. Prolong drug half-lives
Rationale: Pediatric PK.
Practitioners: Practice Test 1 (Units 1-7) - Questions with
Correct Answers
100 questions
1. The FDA MedWatch program is used to:
A. Order medications
B. Set drug prices
C. Prescribe controlled substances
D. Report serious adverse drug events
Correct Answer: D. Report serious adverse drug events
Rationale: Safety reporting.
2. Codeine requires conversion by CYP2D6 to:
A. Hydrocodone
B. Morphine
C. Oxycodone
D. Tramadol
Correct Answer: B. Morphine
Rationale: Ultra-rapid metabolizers risk toxicity.
3. The blood-brain barrier limits:
A. All lipophilic drugs
B. Entry of many hydrophilic and large molecules into the CNS
C. Oxygen
D. Glucose only
Correct Answer: B. Entry of many hydrophilic and large molecules into the CNS
Rationale: Protection.
4. Highly protein-bound drugs may interact because:
A. They are inactive
B. They are excreted faster
C. They can displace each other, increasing free drug levels
D. They cannot be absorbed
Correct Answer: C. They can displace each other, increasing free drug levels
Rationale: Displacement.
5. The first-pass effect refers to:
A. Hepatic metabolism of an oral drug before it reaches systemic circulation
B. Renal excretion
C. Distribution to fat
D. Protein binding
Correct Answer: A. Hepatic metabolism of an oral drug before it reaches systemic circulation
Rationale: Reduces bioavailability.
6. An agonist is a drug that:
A. Blocks a receptor
B. Has no affinity
C. Binds to a receptor and activates it
D. Only binds enzymes
Correct Answer: C. Binds to a receptor and activates it
Rationale: Activation.
,7. Adherence can be improved by:
A. Simplifying regimens, education and addressing cost barriers
B. Increasing pill burden
C. Avoiding explanations
D. Prescribing more drugs
Correct Answer: A. Simplifying regimens, education and addressing cost barriers
Rationale: Patient-centered.
8. A loading dose is used to:
A. Reduce side effects
B. Prolong half-life
C. Avoid metabolism
D. Rapidly achieve therapeutic concentrations for drugs with long half-lives
Correct Answer: D. Rapidly achieve therapeutic concentrations for drugs with long half-lives
Rationale: e.g., amiodarone.
9. Food generally affects drug absorption by:
A. Having no effect
B. Altering gastric emptying, pH and binding
C. Always increasing absorption
D. Always blocking absorption
Correct Answer: B. Altering gastric emptying, pH and binding
Rationale: Instructions matter.
10. The 'start low, go slow' principle is especially important in:
A. Healthy young adults
B. Athletes
C. Adolescents only
D. Older adults
Correct Answer: D. Older adults
Rationale: Geriatric prescribing.
11. Chelation interactions occur when:
A. Drugs increase absorption
B. Drugs are metabolized
C. Drugs are excreted
D. Tetracyclines or fluoroquinolones bind calcium, iron or magnesium, reducing absorption
Correct Answer: D. Tetracyclines or fluoroquinolones bind calcium, iron or magnesium,
reducing absorption
Rationale: Separate doses.
12. The volume of distribution describes:
A. The extent a drug distributes into body tissues versus plasma
B. Bioavailability
C. Excretion rate
D. Half-life only
Correct Answer: A. The extent a drug distributes into body tissues versus plasma
Rationale: Vd.
, 13. A partial agonist such as buprenorphine:
A. Produces maximal effect
B. Has no effect
C. Is a pure antagonist
D. Produces a submaximal effect and can block full agonists
Correct Answer: D. Produces a submaximal effect and can block full agonists
Rationale: Ceiling effect.
14. Drugs with a narrow therapeutic index include:
A. Amoxicillin
B. Loratadine
C. Warfarin, digoxin, lithium, phenytoin and theophylline
D. Acetaminophen at normal dose
Correct Answer: C. Warfarin, digoxin, lithium, phenytoin and theophylline
Rationale: Monitor levels.
15. Patients with CYP2C19 poor metabolizer status may have reduced effectiveness of:
A. Clopidogrel
B. Aspirin
C. Warfarin
D. Heparin
Correct Answer: A. Clopidogrel
Rationale: Prodrug activation.
16. Benzodiazepines in older adults increase the risk of:
A. Falls, fractures, cognitive impairment and delirium
B. Hypertension
C. Hyperglycemia
D. Weight loss
Correct Answer: A. Falls, fractures, cognitive impairment and delirium
Rationale: Beers.
17. Deprescribing involves:
A. Adding drugs
B. Never changing medications
C. Doubling doses
D. Systematically reducing or stopping medications that may no longer be beneficial
Correct Answer: D. Systematically reducing or stopping medications that may no longer be
beneficial
Rationale: Medication review.
18. Neonates have immature hepatic enzymes, which can:
A. Speed metabolism
B. Prolong drug half-lives
C. Increase renal excretion
D. Have no effect
Correct Answer: B. Prolong drug half-lives
Rationale: Pediatric PK.
