Relias RN NICU Nursing Core Concepts — 600 Practice Questions with Verified Answers &
Detailed Rationales
Table of Contents
Exam Overview
Domain 1: Neonatal Transition & Thermoregulation (Questions 1–60)
- Neonatal Transition to Extrauterine Life
- Heat Loss Mechanisms (Conduction, Convection, Radiation, Evaporation)
- Thermoregulation & Neutral Thermal Environment
- Hypothermia & Hyperthermia Management
- Kangaroo Care & Skin-to-Skin Contact
Domain 2: Respiratory System (Questions 61–130)
- Respiratory Distress Syndrome (RDS)
- Transient Tachypnea of the Newborn (TTN)
- Meconium Aspiration Syndrome (MAS)
- Apnea of Prematurity
- Bronchopulmonary Dysplasia (BPD)
- Oxygen Therapy & Ventilation
- Blood Gas Interpretation
Domain 3: Cardiovascular System (Questions 131–190)
- Patent Ductus Arteriosus (PDA)
- Congenital Heart Defects
,- Persistent Pulmonary Hypertension (PPHN)
- Hypotension Management
- Congenital Heart Disease Screening
Domain 4: Neurologic System (Questions 191–240)
- Intraventricular Hemorrhage (IVH)
- Periventricular Leukomalacia (PVL)
- Hypoxic-Ischemic Encephalopathy (HIE)
- Therapeutic Hypothermia
- Neonatal Seizures
Domain 5: Gastrointestinal System (Questions 241–290)
- Necrotizing Enterocolitis (NEC)
- Feeding Intolerance
- Gastroschisis & Omphalocele
- Bilious Aspirate & Gavage Feeding
- Abdominal Assessment
Domain 6: Metabolic & Endocrine (Questions 291–340)
- Hypoglycemia
- Hyperbilirubinemia & Phototherapy
- Congenital Hypothyroidism
- Calcium Disorders
- Inborn Errors of Metabolism
Domain 7: Hematologic System (Questions 341–380)
,- Anemia of Prematurity
- Polycythemia
- Thrombocytopenia
- Vitamin K Deficiency Bleeding (VKDB)
- Blood Product Administration
Domain 8: Infectious Diseases (Questions 381–430)
- Neonatal Sepsis (Early-Onset vs. Late-Onset)
- Group B Streptococcus (GBS) Prophylaxis
- Meningitis
- Congenital Infections (CMV, Toxoplasmosis, Syphilis)
- Infection Prevention & NICU Asepsis
Domain 9: Renal & Fluids (Questions 431–470)
- Fluid & Electrolyte Balance
- Dehydration & Fluid Overload
- Hyponatremia & Hyperkalemia
- Acute Kidney Injury (AKI)
- Urine Output Monitoring
Domain 10: Genetics & Congenital Anomalies (Questions 471–510)
- Common Chromosomal Disorders
- Congenital Anomalies
- Genetic Screening
- Congenital Diaphragmatic Hernia
- Esophageal Atresia & Tracheoesophageal Fistula
, Domain 11: Pharmacology & Medication Safety (Questions 511–550)
- Neonatal Medication Administration
- High-Alert Medications
- Dosage Calculations
- Adverse Effects & Monitoring
- Immunizations
Domain 12: Family-Centered Care & Psychosocial Support (Questions 551–580)
- Family Integration in NICU
- Developmental Care
- Parental Stress & Coping
- Discharge Planning
- Palliative & End-of-Life Care
Domain 13: Professional Practice & Safety (Questions 581–600)
- Patient Safety & Quality Improvement
- Ethical & Legal Issues
- Documentation & Handoff
- Evidence-Based Practice
Exam Overview
The Relias RN NICU Nursing Core Concepts examination is a comprehensive assessment
designed to evaluate the knowledge and clinical judgment of registered nurses caring for
neonates in the Neonatal Intensive Care Unit (NICU). The examination aligns with the National
Detailed Rationales
Table of Contents
Exam Overview
Domain 1: Neonatal Transition & Thermoregulation (Questions 1–60)
- Neonatal Transition to Extrauterine Life
- Heat Loss Mechanisms (Conduction, Convection, Radiation, Evaporation)
- Thermoregulation & Neutral Thermal Environment
- Hypothermia & Hyperthermia Management
- Kangaroo Care & Skin-to-Skin Contact
Domain 2: Respiratory System (Questions 61–130)
- Respiratory Distress Syndrome (RDS)
- Transient Tachypnea of the Newborn (TTN)
- Meconium Aspiration Syndrome (MAS)
- Apnea of Prematurity
- Bronchopulmonary Dysplasia (BPD)
- Oxygen Therapy & Ventilation
- Blood Gas Interpretation
Domain 3: Cardiovascular System (Questions 131–190)
- Patent Ductus Arteriosus (PDA)
- Congenital Heart Defects
,- Persistent Pulmonary Hypertension (PPHN)
- Hypotension Management
- Congenital Heart Disease Screening
Domain 4: Neurologic System (Questions 191–240)
- Intraventricular Hemorrhage (IVH)
- Periventricular Leukomalacia (PVL)
- Hypoxic-Ischemic Encephalopathy (HIE)
- Therapeutic Hypothermia
- Neonatal Seizures
Domain 5: Gastrointestinal System (Questions 241–290)
- Necrotizing Enterocolitis (NEC)
- Feeding Intolerance
- Gastroschisis & Omphalocele
- Bilious Aspirate & Gavage Feeding
- Abdominal Assessment
Domain 6: Metabolic & Endocrine (Questions 291–340)
- Hypoglycemia
- Hyperbilirubinemia & Phototherapy
- Congenital Hypothyroidism
- Calcium Disorders
- Inborn Errors of Metabolism
Domain 7: Hematologic System (Questions 341–380)
,- Anemia of Prematurity
- Polycythemia
- Thrombocytopenia
- Vitamin K Deficiency Bleeding (VKDB)
- Blood Product Administration
Domain 8: Infectious Diseases (Questions 381–430)
- Neonatal Sepsis (Early-Onset vs. Late-Onset)
- Group B Streptococcus (GBS) Prophylaxis
- Meningitis
- Congenital Infections (CMV, Toxoplasmosis, Syphilis)
- Infection Prevention & NICU Asepsis
Domain 9: Renal & Fluids (Questions 431–470)
- Fluid & Electrolyte Balance
- Dehydration & Fluid Overload
- Hyponatremia & Hyperkalemia
- Acute Kidney Injury (AKI)
- Urine Output Monitoring
Domain 10: Genetics & Congenital Anomalies (Questions 471–510)
- Common Chromosomal Disorders
- Congenital Anomalies
- Genetic Screening
- Congenital Diaphragmatic Hernia
- Esophageal Atresia & Tracheoesophageal Fistula
, Domain 11: Pharmacology & Medication Safety (Questions 511–550)
- Neonatal Medication Administration
- High-Alert Medications
- Dosage Calculations
- Adverse Effects & Monitoring
- Immunizations
Domain 12: Family-Centered Care & Psychosocial Support (Questions 551–580)
- Family Integration in NICU
- Developmental Care
- Parental Stress & Coping
- Discharge Planning
- Palliative & End-of-Life Care
Domain 13: Professional Practice & Safety (Questions 581–600)
- Patient Safety & Quality Improvement
- Ethical & Legal Issues
- Documentation & Handoff
- Evidence-Based Practice
Exam Overview
The Relias RN NICU Nursing Core Concepts examination is a comprehensive assessment
designed to evaluate the knowledge and clinical judgment of registered nurses caring for
neonates in the Neonatal Intensive Care Unit (NICU). The examination aligns with the National
