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ATI RN Pharmacology — 100 Original Practice Questions
Pharmacokinetics & Pharmacodynamics (1–10)
1. The study of what the body does to a drug is called:
A) Pharmacodynamics B) Pharmacokinetics C) Pharmacotherapeutics D) Pharmacognosy
Answer: B
2. The study of what a drug does to the body is called:
A) Pharmacodynamics B) Pharmacokinetics C) Pharmacogenetics D) Pharmacognosy
Answer: A
3. A drug's half-life is the time required for:
A) The drug to be completely excreted
B) Serum concentration to decrease by 50%
C) The drug to reach peak effect
D) The drug to become protein-bound
Answer: B
4. Which route has the slowest onset of action?
A) IV B) IM C) Oral D) Sublingual
Answer: C
5. First-pass effect primarily affects drugs given by which route?
A) IV B) Oral C) Topical D) Sublingual
Answer: B
6. A loading dose is given to:
A) Maintain steady-state levels
B) Rapidly achieve therapeutic drug levels
C) Prevent adverse effects
D) Test for allergy
Answer: B
7. Which organ is primarily responsible for drug metabolism?
A) Kidney B) Liver C) Lung D) Spleen
Answer: B
8. Which organ is primarily responsible for drug excretion?
A) Liver B) Kidney C) Lung D) Skin
Answer: B
9. A drug with a narrow therapeutic index requires:
A) No monitoring B) Routine serum level monitoring C) Higher doses D) IV administration
only
Answer: B
, 2
10. Grapefruit juice interacts with drugs by inhibiting:
A) Renal excretion B) CYP450 3A4 enzymes C) Protein binding D) Gastric acid
Answer: B
Dosage Calculation (11–20)
11. Order: 500 mg. Available: 250 mg tablets. How many tablets?
A) 1 B) 2 C) 3 D) 4
Answer: B
12. Order: 1,000 mL over 8 hours. Drop factor 15 gtt/mL. What is the flow rate?
A) 21 gtt/min B) 31 gtt/min C) 41 gtt/min D) 51 gtt/min
Answer: B (1000 ÷ 480 × 15 = 31)
13. Order: 0.5 g. Available: 250 mg/mL. How many mL?
A) 1 mL B) 2 mL C) 3 mL D) 4 mL
Answer: B
14. A child weighs 22 lb. Ordered dose is 10 mg/kg/day. What is the daily dose?
A) 50 mg B) 100 mg C) 150 mg D) 220 mg
Answer: B (22 lb ÷ 2.2 = 10 kg × 10 mg = 100 mg)
15. Order: 250 mL over 2 hours. What is the hourly rate?
A) 100 mL/hr B) 125 mL/hr C) 150 mL/hr D) 175 mL/hr
Answer: B
16. Order: 40 mg. Available: 80 mg/2 mL. How many mL?
A) 0.5 mL B) 1 mL C) 1.5 mL D) 2 mL
Answer: B
17. A 70 kg patient is ordered 15 mcg/kg/min. What is the total mcg/min?
A) 700 B) 1,050 C) 1,400 D) 1,750
Answer: B
18. Order: 3,000 mL over 24 hours. What is the hourly rate?
A) 100 mL/hr B) 125 mL/hr C) 150 mL/hr D) 175 mL/hr
Answer: B
19. Order: 100 mg. Available: 50 mg/5 mL. How many mL?
A) 5 mL B) 10 mL C) 15 mL D) 20 mL
Answer: B
20. A patient weighs 154 lb. What is the weight in kg?
A) 60 kg B) 65 kg C) 70 kg D) 75 kg
Answer: C (154 ÷ 2.2 = 70)
Cardiovascular Medications (21–35)
ATI RN Pharmacology — 100 Original Practice Questions
Pharmacokinetics & Pharmacodynamics (1–10)
1. The study of what the body does to a drug is called:
A) Pharmacodynamics B) Pharmacokinetics C) Pharmacotherapeutics D) Pharmacognosy
Answer: B
2. The study of what a drug does to the body is called:
A) Pharmacodynamics B) Pharmacokinetics C) Pharmacogenetics D) Pharmacognosy
Answer: A
3. A drug's half-life is the time required for:
A) The drug to be completely excreted
B) Serum concentration to decrease by 50%
C) The drug to reach peak effect
D) The drug to become protein-bound
Answer: B
4. Which route has the slowest onset of action?
A) IV B) IM C) Oral D) Sublingual
Answer: C
5. First-pass effect primarily affects drugs given by which route?
A) IV B) Oral C) Topical D) Sublingual
Answer: B
6. A loading dose is given to:
A) Maintain steady-state levels
B) Rapidly achieve therapeutic drug levels
C) Prevent adverse effects
D) Test for allergy
Answer: B
7. Which organ is primarily responsible for drug metabolism?
A) Kidney B) Liver C) Lung D) Spleen
Answer: B
8. Which organ is primarily responsible for drug excretion?
A) Liver B) Kidney C) Lung D) Skin
Answer: B
9. A drug with a narrow therapeutic index requires:
A) No monitoring B) Routine serum level monitoring C) Higher doses D) IV administration
only
Answer: B
, 2
10. Grapefruit juice interacts with drugs by inhibiting:
A) Renal excretion B) CYP450 3A4 enzymes C) Protein binding D) Gastric acid
Answer: B
Dosage Calculation (11–20)
11. Order: 500 mg. Available: 250 mg tablets. How many tablets?
A) 1 B) 2 C) 3 D) 4
Answer: B
12. Order: 1,000 mL over 8 hours. Drop factor 15 gtt/mL. What is the flow rate?
A) 21 gtt/min B) 31 gtt/min C) 41 gtt/min D) 51 gtt/min
Answer: B (1000 ÷ 480 × 15 = 31)
13. Order: 0.5 g. Available: 250 mg/mL. How many mL?
A) 1 mL B) 2 mL C) 3 mL D) 4 mL
Answer: B
14. A child weighs 22 lb. Ordered dose is 10 mg/kg/day. What is the daily dose?
A) 50 mg B) 100 mg C) 150 mg D) 220 mg
Answer: B (22 lb ÷ 2.2 = 10 kg × 10 mg = 100 mg)
15. Order: 250 mL over 2 hours. What is the hourly rate?
A) 100 mL/hr B) 125 mL/hr C) 150 mL/hr D) 175 mL/hr
Answer: B
16. Order: 40 mg. Available: 80 mg/2 mL. How many mL?
A) 0.5 mL B) 1 mL C) 1.5 mL D) 2 mL
Answer: B
17. A 70 kg patient is ordered 15 mcg/kg/min. What is the total mcg/min?
A) 700 B) 1,050 C) 1,400 D) 1,750
Answer: B
18. Order: 3,000 mL over 24 hours. What is the hourly rate?
A) 100 mL/hr B) 125 mL/hr C) 150 mL/hr D) 175 mL/hr
Answer: B
19. Order: 100 mg. Available: 50 mg/5 mL. How many mL?
A) 5 mL B) 10 mL C) 15 mL D) 20 mL
Answer: B
20. A patient weighs 154 lb. What is the weight in kg?
A) 60 kg B) 65 kg C) 70 kg D) 75 kg
Answer: C (154 ÷ 2.2 = 70)
Cardiovascular Medications (21–35)
